{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:11:33Z","timestamp":1777417893472,"version":"3.51.4"},"reference-count":4,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[1992,9,1]],"date-time":"1992-09-01T00:00:00Z","timestamp":715305600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1992,9]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To report the case of a patient who developed nonthrombocytopenic purpura sequentially following the administration of nifedipine and diltiazem.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA SOURCES:<\/jats:title>\n                    <jats:p>Case reports, MEDLINE review of pertinent literature, and review of relevant studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA EXTRACTION:<\/jats:title>\n                    <jats:p>Data were extracted from direct patient observation and review of laboratory studies and published reports.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA SYNTHESIS:<\/jats:title>\n                    <jats:p>Nonthrombocytopenic purpura secondary to cutaneous vasculitis is a known, although rare, adverse effect of nifedipine. It has not been reported in association with diltiazem. We report the case of a 75-year-old woman in whom a purpuric rash demonstrated by biopsy to be attributable to cutaneous vasculitis developed in the course of nifedipine therapy. The rash disappeared after discontinuation of the drug; however, it recurred when diltiazem therapy was initiated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Nonthrombocytopenic purpura may be associated with diltiazem as well as with nifedipine. When this adverse effect occurs following administration of a calcium-channel blocker, caution is advised in using other agents of the same class.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/106002809202600908","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T06:35:00Z","timestamp":1484202900000},"page":"1089-1090","source":"Crossref","is-referenced-by-count":14,"title":["Nonthrombocytopenic Purpura Associated Sequentially with Nifedipine and Diltiazem"],"prefix":"10.1177","volume":"26","author":[{"given":"Margaret","family":"Kuo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Winiarski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serafino","family":"Garella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1992,9,1]]},"reference":[{"key":"bibr-bibr1-106002809202600908","first-page":"3","volume":"108","author":"Brenner S","year":"1985","journal-title":"Harefuah"},{"key":"bibr-bibr2-106002809202600908","first-page":"367","volume":"41","author":"Leibovici V","year":"1988","journal-title":"Cutis"},{"key":"bibr-bibr3-106002809202600908","first-page":"88","volume":"23","author":"Oren R","year":"1989","journal-title":"Drug Intell Clin Pharm"},{"key":"bibr-bibr4-106002809202600908","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.297.6647.562-f"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809202600908","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809202600908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:06:02Z","timestamp":1777374362000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/106002809202600908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,9]]},"references-count":4,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1992,9]]}},"alternative-id":["10.1177\/106002809202600908"],"URL":"https:\/\/doi.org\/10.1177\/106002809202600908","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,9]]}}}