{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:10:15Z","timestamp":1784628615202,"version":"3.55.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[1992,10,1]],"date-time":"1992-10-01T00:00:00Z","timestamp":717897600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1992,10]]},"abstract":"\n OBJECTIVE:<\/jats:title>\n \n To discuss the potential of histamine H\n 2<\/jats:sub>\n -receptor antagonists (H\n 2<\/jats:sub>\n RAs) to cause malabsorption of vitamin B\n 12<\/jats:sub>\n (cyanocobalamin).\n <\/jats:p>\n <\/jats:sec>\n \n DATA SOURCES:<\/jats:title>\n Pertinent literature was identified via a MEDLINE search. Journals and references cited in published articles also were used as data sources.<\/jats:p>\n <\/jats:sec>\n \n STUDY SELECTION:<\/jats:title>\n \n Studies evaluating the effect of H\n 2<\/jats:sub>\n RAs on vitamin B\n 12<\/jats:sub>\n absorption were reviewed.\n <\/jats:p>\n <\/jats:sec>\n \n DATA SYNTHESIS:<\/jats:title>\n \n H\n 2<\/jats:sub>\n RAs decrease acid secretion by the gastric parietal cells. Gastric acid and pepsin produced by these cells are required for the cleavage of vitamin B\n 12<\/jats:sub>\n from dietary sources. Intrinsic factor (IF), also produced by gastric parietal cells, is required for vitamin B\n 12<\/jats:sub>\n absorption from the gastrointestinal tract. Although H\n 2<\/jats:sub>\n RAs have not conclusively been shown to decrease IF secretion, studies have demonstrated a significant reduction in food-bound vitamin B\n 12<\/jats:sub>\n absorption secondary to decreased acid secretion in patients taking these drugs.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n \n H\n 2<\/jats:sub>\n RAs have the potential to cause vitamin B\n 12<\/jats:sub>\n deficiency. This may be important in patients with inadequate stores of vitamin B\n 12<\/jats:sub>\n (e.g., poor diet), particularly those receiving H\n 2<\/jats:sub>\n RA therapy continuously for more than two years. Healthcare providers should be aware of this potential adverse effect.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/106002809202601018","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T09:02:09Z","timestamp":1484125329000},"page":"1283-1286","source":"Crossref","is-referenced-by-count":37,"title":["Effect of Histamine H\n 2<\/sub>\n -Receptor Antagonists on Vitamin B\n 12<\/sub>\n Absorption"],"prefix":"10.1177","volume":"26","author":[{"given":"Rex W.","family":"Force","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milap C.","family":"Nahata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1992,10,1]]},"reference":[{"key":"bibr-bibr1-106002809202601018","unstructured":"McEvoy GK, ed. American Hospital Formulary Service drug information 92. Bethesda, MD: American Society of Hospital Pharmacists, 1992: 1754\u201384."},{"key":"bibr-bibr2-106002809202601018","first-page":"1051","volume-title":"Applied therapeutics: The clinical use of drugs","author":"Bolinger AM","year":"1988","edition":"4"},{"key":"bibr-bibr3-106002809202601018","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19680013"},{"key":"bibr-bibr4-106002809202601018","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/20.6.636"},{"key":"bibr-bibr5-106002809202601018","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(78)90764-3"},{"key":"bibr-bibr6-106002809202601018","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6116.818-a"},{"key":"bibr-bibr7-106002809202601018","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.285.6337.264"},{"key":"bibr-bibr8-106002809202601018","first-page":"118","volume":"4","author":"Mohammed R","year":"1981","journal-title":"Clin Ther"},{"key":"bibr-bibr9-106002809202601018","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(74)90169-X"},{"key":"bibr-bibr10-106002809202601018","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1976.tb140431.x"},{"key":"bibr-bibr11-106002809202601018","doi-asserted-by":"publisher","DOI":"10.1007\/BF01297127"},{"key":"bibr-bibr12-106002809202601018","doi-asserted-by":"publisher","DOI":"10.3109\/00365528009181464"},{"key":"bibr-bibr13-106002809202601018","doi-asserted-by":"publisher","DOI":"10.3109\/00365528509089208"},{"key":"bibr-bibr14-106002809202601018","doi-asserted-by":"publisher","DOI":"10.1007\/BF01308115"},{"key":"bibr-bibr15-106002809202601018","doi-asserted-by":"publisher","DOI":"10.1007\/BF01308137"},{"key":"bibr-bibr16-106002809202601018","doi-asserted-by":"publisher","DOI":"10.3109\/00365528209181056"},{"key":"bibr-bibr17-106002809202601018","doi-asserted-by":"publisher","DOI":"10.1007\/BF01299929"},{"key":"bibr-bibr18-106002809202601018","doi-asserted-by":"publisher","DOI":"10.3109\/00365528509093753"},{"key":"bibr-bibr19-106002809202601018","doi-asserted-by":"publisher","DOI":"10.3109\/00365528708991952"},{"key":"bibr-bibr20-106002809202601018","doi-asserted-by":"publisher","DOI":"10.3109\/00365528708991873"},{"key":"bibr-bibr21-106002809202601018","doi-asserted-by":"publisher","DOI":"10.1136\/gut.26.6.594"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809202601018","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809202601018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:04:45Z","timestamp":1777374285000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/106002809202601018"}},"subtitle":[],"editor":[{"given":"Edward A.","family":"Hartshorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[1992,10]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1992,10]]}},"alternative-id":["10.1177\/106002809202601018"],"URL":"https:\/\/doi.org\/10.1177\/106002809202601018","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,10]]}}}