{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:17:12Z","timestamp":1777418232350,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1993,4,1]],"date-time":"1993-04-01T00:00:00Z","timestamp":733622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1993,4]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To evaluate the effect of a single dose of enteric-coated aspirin (ECA) in three different dosages on platelet function and thromboxane generation in middle-aged men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN AND METHODS:<\/jats:title>\n                    <jats:p>In a nonblind, nonplacebo-controlled, crossover study, a single dose of ECA (50, 250, or 1000 mg) was given in a tablet form to a group of healthy, middle-aged men. Ten subjects, aged 50\u201367 years, volunteered to participate in this study. Platelet functions including bleeding time, platelet aggregation, adenine nucleotides, beta-thromboglobulin, platelet factor 4, thromboxane generation, and aspirin measurement were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Before ECA ingestion, the intracellular adenine nucleotides (adenosine triphosphate, adenosine diphosphate) were decreased, and both beta-thromboglobulin and platelet factor 4 were increased. These observations suggested that platelets were activated in vivo in middle-aged men. These findings returned to normal within 8 hours after the ingestion of ECA, and maintained normal for at least two days. Bleeding time was significantly prolonged at 8 and 24 hours compared with that before ingestion of ECA 1000 mg (p&lt;0.05). The generation of platelet thromboxane was maximally inhibited by approximately 40 percent in the samples 8 hours after ECA ingestion. Abnormal values of adenine nucleotides, beta-thromboglobulin, and platelet factor 4 returned to normal within 8 hours. Arachidonic acid-induced platelet aggregation was inhibited compared with that before treatment (p&lt;0.01) and the inhibitory effect was maintained for at least three days. Adenosine diphosphate- and epinephrine-induced aggregations were less inhibited than those induced by arachidonic acid. Inhibitory effects of ECA on platelet aggregation were dose dependent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Our study indicates that platelets are activated in middle-aged men and that a single dose of ECA 50 mg is safe and can inhibit thromboxane synthesis and platelet aggregation. These results suggest that a daily dose of ECA 50 mg may be useful for blocking platelet activation and preventing thrombosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/106002809302700401","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T11:24:49Z","timestamp":1484306689000},"page":"405-410","source":"Crossref","is-referenced-by-count":4,"title":["Single-Dose Effect of Enteric-Coated Aspirin on Platelet Function and Thromboxane Generation in Middle-Aged Men"],"prefix":"10.1177","volume":"27","author":[{"given":"Hiroshi","family":"Mohri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Ohkubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1993,4,1]]},"reference":[{"key":"bibr-bibr1-106002809302700401","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(77)80351-7"},{"key":"bibr-bibr2-106002809302700401","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.8.3.301"},{"key":"bibr-bibr3-106002809302700401","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110313251801"},{"key":"bibr-bibr4-106002809302700401","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92233-R"},{"key":"bibr-bibr5-106002809302700401","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198511283132201"},{"key":"bibr-bibr6-106002809302700401","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198308183090703"},{"key":"bibr-bibr7-106002809302700401","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92336-G"},{"key":"bibr-bibr8-106002809302700401","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.8.3073"},{"key":"bibr-bibr9-106002809302700401","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108941"},{"key":"bibr-bibr10-106002809302700401","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-195608000-00001"},{"key":"bibr-bibr11-106002809302700401","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109203"},{"key":"bibr-bibr12-106002809302700401","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198304073081402"},{"key":"bibr-bibr13-106002809302700401","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110576"},{"key":"bibr-bibr14-106002809302700401","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)90516-4"},{"key":"bibr-bibr15-106002809302700401","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110814"},{"key":"bibr-bibr16-106002809302700401","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.296.6618.316"},{"key":"bibr-bibr17-106002809302700401","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1656307"},{"key":"bibr-bibr18-106002809302700401","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.2510040107"},{"key":"bibr-bibr19-106002809302700401","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1983.47"},{"key":"bibr-bibr20-106002809302700401","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.11.1.9"},{"key":"bibr-bibr21-106002809302700401","first-page":"1","volume":"27","author":"Breddin 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