{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:16:49Z","timestamp":1777418209361,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1993,4,1]],"date-time":"1993-04-01T00:00:00Z","timestamp":733622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1993,4]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To present cases supporting the hypothesis that fluconazole inhibition of cyclosporine metabolism is dose-dependent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN:<\/jats:title>\n                    <jats:p>Case reports.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENTS AND INTERVENTIONS:<\/jats:title>\n                    <jats:p>One renal-pancreatic transplant patient taking fluconazole 100 and 300 mg\/d for 37 and 17 days, respectively; four bone marrow transplant recipients taking fluconazole 100 mg\/d as antifungal prophylaxis and five other concurrent nonmatched recipients whose antifungal prophylactic agent is nystatin mouthwash. All of these patients underwent transplantation during the same period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      There was a sharp rise in cyclosporine trough concentration (ng\/mL), concentration: dose ratio (ng\u00b7mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      \/mg\u00b7kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      ), and serum creatinine concentration (\u03bcmol\/L) in the renal-pancreatic transplantation patient taking fluconazole 300 mg\/d. No such increase occurred at 100 mg\/d. No significant alterations in cyclosporine concentration:dose ratio were seen in the patients undergoing bone marrow transplantation and receiving fluconazole 100 mg\/d.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The case of the renal-pancreatic transplantation patient shows a characteristic interaction profile, and it supports the hypothesis of a dose-dependent interaction between cyclosporine and fluconazole. Given the nephrotoxic potential of the immunosuppressant drug, dosage reduction and closer monitoring of cyclosporine concentrations and\/or renal function in patients receiving fluconazole dosages greater than 200 mg\/d must be considered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/106002809302700405","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T11:24:49Z","timestamp":1484306689000},"page":"427-430","source":"Crossref","is-referenced-by-count":58,"title":["Fluconazole-Cyclosporine Interaction: A Dose-Dependent Effect?"],"prefix":"10.1177","volume":"27","author":[{"given":"J. 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