{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:21:12Z","timestamp":1777418472511,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[1993,9,1]],"date-time":"1993-09-01T00:00:00Z","timestamp":746841600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To report a case of sulfasalazine-induced agranulocytosis that was successfully treated with granulocyte-colony stimulating factor (G-CSF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY:<\/jats:title>\n                    <jats:p>An 82-year-old woman developed agranulocytosis within two months of initiating sulfasalazine therapy. She was hospitalized, empiric antibiotics and antifungal agents were prescribed, and sulfasalazine therapy was stopped. The patient received G-CSF 600 \u03bcg\/d subcutaneously for six consecutive days, starting on hospital day 5. Agranulocytosis resolved on day 5 and leukopenia on day 6 of G-CSF therapy. No adverse reactions were attributed to administration of this agent and the patient was discharged on hospital day 13.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Numerous agents, including sulfasalazine, have been associated with agranulocytosis. Agranulocytic patients frequently experience life-threatening bacterial and fungal infections. Administration of colony stimulating factors may reduce the duration of agranulocytosis and incidence of life-threatening infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>G-CSF administration appears to have decreased the duration of this elderly patient's agranulocytosis and hospitalization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/106002809302700907","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T10:42:10Z","timestamp":1484131330000},"page":"1052-1054","source":"Crossref","is-referenced-by-count":6,"title":["Granulocyte-Colony Stimulating Factor for Sulfasalazine-Induced Agranulocytosis"],"prefix":"10.1177","volume":"27","author":[{"given":"Barry J.","family":"Gales","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Gales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1993,9,1]]},"reference":[{"key":"bibr-bibr1-106002809302700907","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.293.6544.420"},{"key":"bibr-bibr2-106002809302700907","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/29.5.407"},{"key":"bibr-bibr3-106002809302700907","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/28.5.414"},{"key":"bibr-bibr4-106002809302700907","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197309062891001"},{"key":"bibr-bibr5-106002809302700907","doi-asserted-by":"publisher","DOI":"10.1177\/106002808802200208"},{"key":"bibr-bibr6-106002809302700907","first-page":"214","volume":"24","author":"Pullar T","year":"1985","journal-title":"Br J Rheumatol"},{"key":"bibr-bibr7-106002809302700907","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/28.4.364"},{"key":"bibr-bibr8-106002809302700907","first-page":"420","volume-title":"Introduction to hematology","author":"Rapaport SI","year":"1987","edition":"2"},{"key":"bibr-bibr9-106002809302700907","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-111-7-621_2"},{"key":"bibr-bibr10-106002809302700907","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-110-11-942_2"},{"key":"bibr-bibr11-106002809302700907","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90305-X"},{"key":"bibr-bibr12-106002809302700907","doi-asserted-by":"publisher","DOI":"10.1177\/106002809202600907"},{"key":"bibr-bibr13-106002809302700907","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830370411"},{"key":"bibr-bibr14-106002809302700907","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/13.3.523"},{"key":"bibr-bibr15-106002809302700907","first-page":"179","volume":"12","author":"Rospond RM","year":"1993","journal-title":"Clin Pharm"},{"key":"bibr-bibr16-106002809302700907","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198631010-00004"},{"key":"bibr-bibr17-106002809302700907","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1985.tb02813.x"},{"key":"bibr-bibr18-106002809302700907","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1972.tb00909.x"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809302700907","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809302700907","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:07:20Z","timestamp":1777374440000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/106002809302700907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,9]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1993,9]]}},"alternative-id":["10.1177\/106002809302700907"],"URL":"https:\/\/doi.org\/10.1177\/106002809302700907","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,9]]}}}