{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:17:38Z","timestamp":1792192658760,"version":"4.4.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[1993,10,1]],"date-time":"1993-10-01T00:00:00Z","timestamp":749433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1993,10]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To report a case of clozapine- and molindone-induced agranulocytosis and to discuss treatment using filgrastim, a granulocyte colony-stimulating factor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY:<\/jats:title>\n                    <jats:p>\n                      A 64-year-old woman who had been on long-term clozapine therapy for schizophrenia was hospitalized with presumed drug-induced agranulocytosis. She had also been on short-term molindone therapy. A bone marrow biopsy and the initial white blood cell (WBC) count were consistent with drug-induced agranulocytosis. Following seven days of treatment with subcutaneous filgrastim 300 \u03bcg\/d, her absolute neutrophil count was above 500 \u00d7 10\n                      <jats:sup>6<\/jats:sup>\n                      \/L.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION:<\/jats:title>\n                    <jats:p>Reports in the literature discussing antipsychotic drug-induced agranulocytosis are reviewed. A relationship between treatment with filgrastim and WBC response is postulated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Filgrastim may be useful in ameliorating the effects of clozapine- and molindone-induced agranulocytosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/106002809302701006","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T09:17:15Z","timestamp":1484299035000},"page":"1190-1192","source":"Crossref","is-referenced-by-count":12,"title":["Treatment of Clozapine- and Molindone-Induced Agranulocytosis with Granulocyte Colony-Stimulating Factor"],"prefix":"10.1177","volume":"27","author":[{"given":"Charles B.","family":"Geibig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis W.","family":"Marks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1993,10,1]]},"reference":[{"key":"bibr-bibr1-106002809302701006","doi-asserted-by":"publisher","DOI":"10.1177\/106002809002400721"},{"key":"bibr-bibr2-106002809302701006","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198911233212106"},{"key":"bibr-bibr3-106002809302701006","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198806023182202"},{"key":"bibr-bibr4-106002809302701006","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199107183250305"},{"key":"bibr-bibr5-106002809302701006","doi-asserted-by":"publisher","DOI":"10.1177\/106002809202600907"},{"key":"bibr-bibr6-106002809302701006","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90305-X"},{"key":"bibr-bibr7-106002809302701006","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)93116-5"},{"key":"bibr-bibr8-106002809302701006","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800330013001"},{"key":"bibr-bibr9-106002809302701006","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-198712000-00002"},{"key":"bibr-bibr10-106002809302701006","first-page":"105","volume-title":"Meyler's side effects of drugs","author":"Simpson GM","year":"1988","edition":"11"},{"key":"bibr-bibr11-106002809302701006","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1977.tb00224.x"},{"key":"bibr-bibr12-106002809302701006","volume-title":"Product information. Clozaril (Clozapine)","year":"1991"},{"key":"bibr-bibr13-106002809302701006","doi-asserted-by":"publisher","DOI":"10.1007\/BF00442575"},{"key":"bibr-bibr14-106002809302701006","first-page":"268","volume":"9","author":"Owne R","year":"1989","journal-title":"J Clin Psychopharmacol"},{"key":"bibr-bibr15-106002809302701006","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.1990.11716370"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809302701006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809302701006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:06:16Z","timestamp":1777374376000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/106002809302701006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,10]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1993,10]]}},"alternative-id":["10.1177\/106002809302701006"],"URL":"https:\/\/doi.org\/10.1177\/106002809302701006","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,10]]}}}