{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:10:20Z","timestamp":1777417820732,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1994,3,1]],"date-time":"1994-03-01T00:00:00Z","timestamp":762480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1994,3]]},"abstract":"\n OBJECTIVE:<\/jats:title>\n To report a case of a possible hypersensitivity reaction induced by metronidazole.<\/jats:p>\n <\/jats:sec>\n \n CASE SUMMARY:<\/jats:title>\n An Asian woman with a history of recurrent vaginitis had previously developed localized erythema while on intravaginal metronidazole and nystatin. While receiving oral metronidazole for treatment of a current bacterial vaginosis, she developed chills, fever, generalized erythema, and a rash within 60 minutes of the first dose. Treatment with diphenhydramine was instituted. The following day while in the hospital, the patient's condition worsened; she experienced shortness of breath and increased edema of the extremities. Methylprednisolone was administered with diphenhydramine and her condition improved over the next 5 days. The patient's vaginitis was treated with gentian violet and she was discharged on a tapering dosage of prednisone.<\/jats:p>\n <\/jats:sec>\n \n DISCUSSION:<\/jats:title>\n Metronidazole-induced cutaneous reactions and systemic hypersensitivity reactions are reviewed. Alternatives to metronidazole and other potential cross-reactive drugs are suggested for the treatment of recurrent vaginitis.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n Although the patient's initial reaction to metronidazole represented a rare event, written documentation and communication in the patient's native language may have prevented the subsequent severe hypersensitivity reaction.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/106002809402800305","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T10:25:55Z","timestamp":1484130355000},"page":"325-326","source":"Crossref","is-referenced-by-count":28,"title":["Metronidazole Hypersensitivity"],"prefix":"10.1177","volume":"28","author":[{"given":"Sandra","family":"Knowles","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taffik","family":"Choudhury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil H.","family":"Shear","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1994,3,1]]},"reference":[{"key":"bibr-bibr1-106002809402800305","unstructured":"McEvoy GK, ed. 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