{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:13:26Z","timestamp":1777418006830,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"7-8","license":[{"start":{"date-parts":[[1994,7,1]],"date-time":"1994-07-01T00:00:00Z","timestamp":773020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To determine whether beta-blocker withdrawal under close medical supervision poses undue risks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN:<\/jats:title>\n                    <jats:p>Retrospective case review. Data extracted from previous study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SUBJECTS:<\/jats:title>\n                    <jats:p>114 hypertensive subjects tapered from beta-blocker therapy. Subjects were a subset of patients originally studied for blood pressure medication withdrawal and biofeedback training.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MAIN OUTCOME MEASURES:<\/jats:title>\n                    <jats:p>Frequency of symptoms and adverse effects reported by subjects during medication taper to the study nurse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Symptoms were no more likely to occur with beta-blocker withdrawal than with withdrawal of other types of antihypertensive medications. Most adverse effects were classified as minor. Two subjects experienced major symptoms. One subject required reinstitution of beta-blockers for palpitations, and another exhibited angina upon beta-blocker withdrawal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In well-screened patients under careful monitoring, withdrawal from beta-blockers appears to present a small, manageable risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/106002809402800704","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T07:36:42Z","timestamp":1483688202000},"page":"849-851","source":"Crossref","is-referenced-by-count":2,"title":["Close Clinical Observation Minimizes the Complications of Beta-Blocker Withdrawal"],"prefix":"10.1177","volume":"28","author":[{"given":"George","family":"Eisele","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda L.","family":"Gilmore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward B.","family":"Blanchard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1994,7,1]]},"reference":[{"key":"bibr1-106002809402800704","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)90038-5"},{"key":"bibr2-106002809402800704","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(88)90627-8"},{"key":"bibr3-106002809402800704","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1981.00340090021007"},{"key":"bibr4-106002809402800704","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03440120075040"},{"key":"bibr5-106002809402800704","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-7894(86)80095-8"},{"key":"bibr6-106002809402800704","doi-asserted-by":"publisher","DOI":"10.1007\/BF00999145"},{"key":"bibr7-106002809402800704","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.7.Suppl.175"},{"key":"bibr8-106002809402800704","doi-asserted-by":"publisher","DOI":"10.1007\/BF01000564"},{"key":"bibr9-106002809402800704","doi-asserted-by":"publisher","DOI":"10.1007\/BF00999082"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809402800704","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809402800704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:06:19Z","timestamp":1777374379000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/106002809402800704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,7]]},"references-count":9,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[1994,7]]}},"alternative-id":["10.1177\/106002809402800704"],"URL":"https:\/\/doi.org\/10.1177\/106002809402800704","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,7]]}}}