{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:58:13Z","timestamp":1789379893806,"version":"build-2803163510"},"reference-count":33,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1995,6,1]],"date-time":"1995-06-01T00:00:00Z","timestamp":801964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To report a case of fatal hepatotoxicity associated with the chronic use of oral amiodarone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Summary:<\/jats:title>\n                    <jats:p>Long-term administration of amiodarone for the control of intractable ventricular tachycardia was associated with fatal hepatotoxicity in a patient receiving amiodarone for 14 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Although most hepatic adverse effects associated with amiodarone are transient and reversible with time, deaths resulting from amiodarone-induced hepatotoxicity have been reported. The relation of hepatotoxicity to cumulative dose and duration of therapy is debated. The histopathologic features of amiodarone-induced hepatotoxicity include Mallory bodies, steatosis, intralobular inflammatory infiltrates, fibrosis, and phospholipidosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Evidence pertaining to both mild and severe amiodarone toxicity indicates that cumulative dose may correlate with overall toxicity and, therefore, maintenance doses should be kept as low as possible. Patients should be followed with monitoring of liver function test results every 3\u20136 months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/106002809502900605","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T10:24:44Z","timestamp":1484303084000},"page":"582-586","source":"Crossref","is-referenced-by-count":37,"title":["Fatal Hepatotoxicity Following Oral Administration of Amiodarone"],"prefix":"10.1177","volume":"29","author":[{"given":"Monique","family":"Richer","sequence":"first","affiliation":[{"name":"\u00c9cole de Pharmacie, Universit\u00e9 Laval, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Robert","sequence":"additional","affiliation":[{"name":"\u00c9cole de Pharmacie. Universit\u00e9 Laval"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1995,6,1]]},"reference":[{"key":"bibr1-106002809502900605","doi-asserted-by":"crossref","unstructured":"GillJ, HeelRC, FittonA. Amiodarone. Drags 1992;43:69-110.","DOI":"10.2165\/00003495-199243010-00007"},{"key":"bibr2-106002809502900605","unstructured":"AdamsPC, BennettMK, HoltDW. Hepatic effects of amiodarone. Br J Clin Pract 1986;44:81-95."},{"key":"bibr3-106002809502900605","doi-asserted-by":"crossref","unstructured":"FogorosRN, AndersonKP, WinkleRA, SwerdlowCD, MasonJW. Amiodarone: clinical efficacy and toxicity in 96 patients with recurrent, drug refractory arrhythmias. Circulation 1983;68:88-94.","DOI":"10.1161\/01.CIR.68.1.88"},{"key":"bibr4-106002809502900605","doi-asserted-by":"crossref","unstructured":"HarrisL, McKennaWJ, RowlandE, HoltDW, StoreyGCA, KriklerDM. Side effects of long-term amiodarone therapy. 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Neuropathy and fatal hepatitis in a patient receiving amiodarone. Br Med J 1984;288:1638-9.","DOI":"10.1136\/bmj.288.6431.1638"},{"key":"bibr9-106002809502900605","doi-asserted-by":"crossref","unstructured":"RinderHM, LoveJC, WexlerR. Amiodarone hepatotoxicity. N Engl J Med 1986;314:318-9.","DOI":"10.1056\/NEJM198601303140516"},{"key":"bibr10-106002809502900605","unstructured":"GilinskyNH, BriscoeGW, KuoC. Fatal amiodarone hepatotoxicity. Am J Gastroenterol 1988;83:161-3."},{"key":"bibr11-106002809502900605","doi-asserted-by":"crossref","unstructured":"RocheJF, NetterP, GayG. H\u00e9patites \u00e0 l'amiodarone: diagnostic biologique, histologique, \u00e9volution et r\u00f4les des facteurs associ\u00e9s. Revue de la litt\u00e9rature. Rev Med Interne 1989;10:497-501.","DOI":"10.1016\/S0248-8663(89)80065-7"},{"key":"bibr12-106002809502900605","doi-asserted-by":"crossref","unstructured":"RigasB, RosenfeldLE, BarwickKW, EnriquezR, HeizbergJ, BatsfordWP, Amiodarone hepatotoxicity. 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