{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:27:49Z","timestamp":1777418869265,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1996,2,1]],"date-time":"1996-02-01T00:00:00Z","timestamp":823132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1996,2]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To evaluate the effect of concurrent ranitidine therapy on theophylline metabolism in healthy Koreans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN:<\/jats:title>\n                    <jats:p>A 4-week, double-blind, randomized, placebo-controlled, crossover study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SETTING:<\/jats:title>\n                    <jats:p>The Clinical Research Unit, Department of Pharmaceutical Sciences, Yanbian Medical College, Yanji, China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SUBJECTS:<\/jats:title>\n                    <jats:p>Six young, healthy, nonsmoking Korean volunteers residing in China with no known factors that would alter theophylline metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>INTERVENTIONS:<\/jats:title>\n                    <jats:p>\n                      Subjects received extended-release oral theophylline at a constant dosage over 4 weeks to yield a serum concentration (C\n                      <jats:sub>p<\/jats:sub>\n                      ) between 5 and 10 \u03bcg\/mL. Week 1 was the dosage titration phase. During week 2 subjects randomly received either ranitidine or a matching placebo. Week 3 was a washout phase, and during week 4 subjects were crossed over to receive either placebo or ranitidine. At the end of each treatment week, serum and urinary metabolite concentrations were measured.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OUTCOME MEASURES:<\/jats:title>\n                    <jats:p>\n                      Theophylline serum concentrations and urinary concentrations of 1-methylxanthine, 1-methyluric acid, 3-methylxanthine, and 1,3-dimethyluric acid were measured. Estimates of clearance (Cl), volume of distribution (V\n                      <jats:sub>d<\/jats:sub>\n                      ), and half-life (t\n                      <jats:sub>1\/2<\/jats:sub>\n                      ) were determined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Concurrent administration of ranitidine with theophylline did not significantly alter theophylline C\n                      <jats:sub>p<\/jats:sub>\n                      , Cl, V\n                      <jats:sub>d<\/jats:sub>\n                      , or t\n                      <jats:sub>1\/2<\/jats:sub>\n                      . Urinary concentrations of major theophylline metabolites also were not changed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Ranitidine does not significantly alter the metabolism of theophylline in healthy Koreans residing in China.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/106002809603000204","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T08:06:46Z","timestamp":1484294806000},"page":"133-137","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Ranitidine on Theophylline Metabolism in Healthy Koreans Living in China"],"prefix":"10.1177","volume":"30","author":[{"given":"William A","family":"Kehoe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles D","family":"Sands","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li Feng","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han Hui","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur F","family":"Harralson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Taek","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel W","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1996,2,1]]},"reference":[{"key":"bibr-bibr1-106002809603000204","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198836010-00006"},{"key":"bibr-bibr2-106002809603000204","first-page":"S38","volume":"24","author":"Hansten PD","year":"1990","journal-title":"DICP Ann Pharmacother"},{"key":"bibr-bibr3-106002809603000204","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-3-459_1"},{"key":"bibr-bibr4-106002809603000204","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-102-4-559_1"},{"key":"bibr-bibr5-106002809603000204","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(88)80089-5"},{"key":"bibr-bibr6-106002809603000204","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(89)90246-5"},{"key":"bibr-bibr7-106002809603000204","doi-asserted-by":"publisher","DOI":"10.1177\/106002809102500104"},{"key":"bibr-bibr8-106002809603000204","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1982.36"},{"key":"bibr-bibr9-106002809603000204","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1984.00350150068021"},{"key":"bibr-bibr10-106002809603000204","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1986.99"},{"key":"bibr-bibr11-106002809603000204","doi-asserted-by":"publisher","DOI":"10.1007\/BF00314801"},{"key":"bibr-bibr12-106002809603000204","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1992.tb03865.x"},{"key":"bibr-bibr13-106002809603000204","first-page":"383","volume":"15","author":"Fraser IM","year":"1993","journal-title":"Clin Ther"},{"key":"bibr-bibr14-106002809603000204","first-page":"56","volume":"20","author":"Lee EJ","year":"1991","journal-title":"Ann Acad Med Singapore"},{"key":"bibr-bibr15-106002809603000204","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1990.tb03681.x"},{"key":"bibr-bibr16-106002809603000204","doi-asserted-by":"publisher","DOI":"10.1177\/106002809402800319"},{"key":"bibr-bibr17-106002809603000204","first-page":"315","volume-title":"Basic clinical pharmacokinetics","author":"Winter ME","year":"1988"},{"key":"bibr-bibr18-106002809603000204","first-page":"1105","volume-title":"Applied pharmacokinetics. Principles of therapeutic drug monitoring","author":"Slaughter R","year":"1986"},{"key":"bibr-bibr19-106002809603000204","unstructured":"Friedman LM, Furberg CD, DeMets DL. Fundamentals of clinical trials. Boston: John Wright, 1980: 69\u201388."},{"key":"bibr-bibr20-106002809603000204","first-page":"15","volume-title":"Research design and analysis","author":"Kroboth PD","year":"1986"},{"key":"bibr-bibr21-106002809603000204","unstructured":"Kirk RE. Experimental design. 2nd ed. Pacific Grove, CA: Brooks\/Cole Publishing, 1982: 142\u20134."},{"key":"bibr-bibr22-106002809603000204","first-page":"1004","volume":"33","author":"Kehoe WA","year":"1993","journal-title":"J Clin Pharmacol"},{"key":"bibr-bibr23-106002809603000204","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199308000-00004"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809603000204","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809603000204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:08:28Z","timestamp":1777374508000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/106002809603000204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,2]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1996,2]]}},"alternative-id":["10.1177\/106002809603000204"],"URL":"https:\/\/doi.org\/10.1177\/106002809603000204","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,2]]}}}