{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:03:21Z","timestamp":1777417401631,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1996,5,1]],"date-time":"1996-05-01T00:00:00Z","timestamp":830908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1996,5]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>TO study the effects of ofloxacin on the reliability of urine glucose testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN:<\/jats:title>\n                    <jats:p>Open-label, nonrandomized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SETTING:<\/jats:title>\n                    <jats:p>A university-affiliated tertiary care hospital, ambulatory clinic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PARTICIPANTS:<\/jats:title>\n                    <jats:p>Ten healthy volunteers (8 men and 2 women) aged 22-39 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MAIN OUTCOME MEASURES:<\/jats:title>\n                    <jats:p>Phase I (in vitro) involved the addition of selected amounts of ofloxacin to a set of standard 50-mL urine samples prepared to simulate glycosuria. Phase II (in vivo) involved the oral administration of ofloxacin 400 mg to 10 subjects. Urine was collected: (1) immediately predose, (2) pooled 0\u20134 hours postdose, and (3) pooled 4\u20138 hours postdose. Known glucose concentrations were then added to these samples. Clinitest and Diastix tests were performed on all samples. The accuracy of these tests in determining glucose concentrations was compared among urine samples taken before and after ofloxacin dosing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>None of the ofloxacin concentrations in phase I (0,25,50, 100, 200,400, and 800 \u03bcg\/mL) influenced these testing methods at the urine glucose concentrations of 0.0%, 0.5%, 1%, and 2%. Likewise, the accuracy of these two tests was unaffected by ofloxacin administration in phase II.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In single-dose administration, ofloxacin does not interfere with Clinitest or Diastix for determining urine glucose concentrations. Supported by a grant from the RW Johnson Pharmaceutical Research Institute. Presented in abstract form at the American College of Clinical Pharmacy 1994 Winter Practice and Research Forum, February 6\u20139, 1994, San Diego. CA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/106002809603000506","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T17:07:14Z","timestamp":1484154434000},"page":"469-472","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Ofloxacin Administration on the Reliability of Urine Glucose Testing"],"prefix":"10.1177","volume":"30","author":[{"given":"Tsong-Mei","family":"Tsai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian F","family":"Shea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul F","family":"Souney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred G","family":"Volinsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph M","family":"Scavone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suellen","family":"O'Neill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1996,5,1]]},"reference":[{"key":"bibr-bibr1-106002809603000506","first-page":"14","volume":"13","author":"Koda-Kimble MA","year":"1988","journal-title":"US Pharm"},{"key":"bibr-bibr2-106002809603000506","first-page":"1499","volume":"39","author":"Kowalsky SF","year":"1982","journal-title":"Am J Hosp Pharm"},{"key":"bibr-bibr3-106002809603000506","first-page":"1493","volume":"38","author":"Paysinger AL","year":"1981","journal-title":"Am J Hosp Pharm"},{"key":"bibr-bibr4-106002809603000506","first-page":"125","volume":"41","author":"MacCara ME","year":"1984","journal-title":"Am J Hosp Pharm"},{"key":"bibr-bibr5-106002809603000506","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1965.03090090052027"},{"key":"bibr-bibr6-106002809603000506","first-page":"602","volume":"42","author":"Tartaglione TA","year":"1985","journal-title":"Am J Hosp Pharm"},{"key":"bibr-bibr7-106002809603000506","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92626-8"},{"key":"bibr-bibr8-106002809603000506","first-page":"24S","volume":"87","author":"Flor S","year":"1989","journal-title":"Am J Med"},{"key":"bibr-bibr9-106002809603000506","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.31.9.1338"},{"key":"bibr-bibr10-106002809603000506","doi-asserted-by":"publisher","DOI":"10.1177\/106002808902301101"},{"key":"bibr-bibr11-106002809603000506","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198733040-00003"},{"key":"bibr-bibr12-106002809603000506","volume-title":"Package insert. Clinitest","year":"1985"},{"key":"bibr-bibr13-106002809603000506","volume-title":"Package insert. Diastix","year":"1985"},{"key":"bibr-bibr14-106002809603000506","volume-title":"Package insert. Floxin (ofloxacin)","year":"1991"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809603000506","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809603000506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:04:41Z","timestamp":1777374281000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/106002809603000506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,5]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1996,5]]}},"alternative-id":["10.1177\/106002809603000506"],"URL":"https:\/\/doi.org\/10.1177\/106002809603000506","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,5]]}}}