{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:04:43Z","timestamp":1777417483219,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"7-8","license":[{"start":{"date-parts":[[1996,7,1]],"date-time":"1996-07-01T00:00:00Z","timestamp":836179200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1996,7]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To describe a patient who developed hepatotoxicity, reactive plasmacytosis with thrombocytosis and life-threatening agranulocytosis, followed by a leukemoid reaction, apparently caused by acute acetaminophen toxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SETTING:<\/jats:title>\n                    <jats:p>University-affiliated hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CASE SUMMARY:<\/jats:title>\n                    <jats:p>A 19-year-old white woman who took an overdose of acetaminophen developed hepatotoxicity and reactive plasmacytosis with thrombocytosis and life-threatening agranulocytosis, followed by a leukemoid reaction. Symptoms, signs, and laboratory findings regressed with symptomatic therapy during the follow-up period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>We believe that acute acetaminophen toxicity was responsible for these hematologic abnormalities. This profile of hematologic adverse effects associated with acetaminophen toxicity has not been reported previously.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/106002809603000710","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T07:41:20Z","timestamp":1483688480000},"page":"762-765","source":"Crossref","is-referenced-by-count":8,"title":["Agranulocytosis, Plasmacytosis, and Thrombocytosis Followed by a Leukemoid Reaction Due to Acute Acetaminophen Toxicity"],"prefix":"10.1177","volume":"30","author":[{"given":"Murat","family":"G\u00fcrsoy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim C","family":"Haznedaro\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"\u00c7elik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilg\u00fcn","family":"Sayinalp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman I","family":"\u00d6zcebe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semra V","family":"D\u00fcndar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantal","family":"Gu\u00e9vremont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1996,7,1]]},"reference":[{"key":"bibr1-106002809603000710","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.21.7227"},{"key":"bibr2-106002809603000710","doi-asserted-by":"publisher","DOI":"10.1542\/peds.55.6.871"},{"key":"bibr3-106002809603000710","first-page":"332","volume":"140","author":"Chichmanian RM","year":"1989","journal-title":"Ann Med Interne (Paris)"},{"key":"bibr4-106002809603000710","first-page":"438","volume":"45","author":"Lacotte J","year":"1990","journal-title":"Therapie"},{"key":"bibr5-106002809603000710","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.40.2.89"},{"key":"bibr6-106002809603000710","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197208242870803"},{"key":"bibr7-106002809603000710","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5872.173-c"},{"key":"bibr8-106002809603000710","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5875.353"},{"key":"bibr9-106002809603000710","doi-asserted-by":"publisher","DOI":"10.1159\/000207064"},{"key":"bibr10-106002809603000710","doi-asserted-by":"publisher","DOI":"10.1007\/BF01727011"},{"key":"bibr11-106002809603000710","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198631010-00004"},{"key":"bibr12-106002809603000710","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1979.tb06084.x"},{"key":"bibr13-106002809603000710","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1972.tb00909.x"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809603000710","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809603000710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:04:56Z","timestamp":1777374296000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/106002809603000710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,7]]},"references-count":13,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[1996,7]]}},"alternative-id":["10.1177\/106002809603000710"],"URL":"https:\/\/doi.org\/10.1177\/106002809603000710","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,7]]}}}