{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:26:11Z","timestamp":1777418771298,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[1996,10,1]],"date-time":"1996-10-01T00:00:00Z","timestamp":844128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1996,10]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To compare the safety and efficacy of cetirizine with that of hydroxyzine and placebo in the treatment of chronic idiopathic urticaria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN:<\/jats:title>\n                    <jats:p>A 4-week multicenter, randomized, double-blind, double-dummy, placebo-controlled safety and efficacy study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SETTING:<\/jats:title>\n                    <jats:p>Patients were treated in a variety of allergy practice settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENTS:<\/jats:title>\n                    <jats:p>The study population consisted of 188 patients who were at least 12 years of age, with symptomatic chronic idiopathic urticaria that had occurred episodically for at least 6 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>INTERVENTIONS:<\/jats:title>\n                    <jats:p>Patients were given either cetirizine 10 mg once daily, hydroxyzine 25 mg tid, or placebo for 4 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MAIN OUTCOME MEASURES:<\/jats:title>\n                    <jats:p>Patients and investigators used a 4-point scale to evaluate symptoms of urticaria and adverse effects of treatment. Ratings were compared among those taking cetirizine, hydroxyzine, or placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>After 1 day of treatment, patients randomized to receive cetirizine 10 mg\/d exhibited a reduction in the number of episodes of urticaria (and a reduction in pruritus) compared with patients who received hydroxyzine 25 mg tid and patients who received placebo (p = 0.002). The number of urticarial episodes in patients treated with hydroxyzine did not reach significance until day 2 (p = 0.001). Compared with patients who received placebo, patients who received cetirizine and those who received hydroxyzine showed reductions during weeks 1, 2, and 3 and at end-point analysis in the number and size of lesions and in the severity of pruritus (p &lt; 0.04). Patient and physician evaluations at the end of week 4 revealed an improvement in urticarial symptoms for the hydroxyzine and cetirizine groups compared with the placebo group (p &lt; 0.001). Four patients in the hydroxyzine group, 1 patient in the cetirizine group, and 1 patient in the placebo group discontinued the study because of sedation. No patient withdrew because of lack of efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Cetirizine 10 mg once daily was equivalent to hydroxyzine 25 mg tid in controlling the symptoms of patients with chronic urticaria, as assessed by patient and investigator evaluations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/106002809603001001","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T12:06:21Z","timestamp":1484309181000},"page":"1075-1079","source":"Crossref","is-referenced-by-count":59,"title":["Cetirizine versus Hydroxyzine and Placebo in Chronic Idiopathic Urticaria"],"prefix":"10.1177","volume":"30","author":[{"given":"Debra L.","family":"Breneman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1996,10,1]]},"reference":[{"key":"bibr-bibr1-106002809603001001","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(05)80246-5"},{"key":"bibr-bibr2-106002809603001001","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(88)70243-1"},{"key":"bibr-bibr3-106002809603001001","first-page":"128","volume":"38","author":"Fredriksson T","year":"1986","journal-title":"Cutis"},{"key":"bibr-bibr4-106002809603001001","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(88)90197-2"},{"key":"bibr-bibr5-106002809603001001","first-page":"189","volume-title":"Allergy and asthma: New trends and approaches to therapy","author":"Wasserman SI","year":"1989"},{"key":"bibr-bibr6-106002809603001001","first-page":"53","volume":"59","author":"Gengo FM","year":"1987","journal-title":"Ann Allergy"},{"key":"bibr-bibr7-106002809603001001","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199040050-00009"},{"key":"bibr-bibr8-106002809603001001","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(86)90266-6"},{"key":"bibr-bibr9-106002809603001001","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(05)80248-9"},{"key":"bibr-bibr10-106002809603001001","doi-asserted-by":"publisher","DOI":"10.1177\/030006059101900213"},{"key":"bibr-bibr11-106002809603001001","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(90)90091-H"},{"key":"bibr-bibr12-106002809603001001","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70251-V"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809603001001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809603001001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:07:58Z","timestamp":1777374478000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/106002809603001001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,10]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1996,10]]}},"alternative-id":["10.1177\/106002809603001001"],"URL":"https:\/\/doi.org\/10.1177\/106002809603001001","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,10]]}}}