{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:11:12Z","timestamp":1777417872272,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1997,4,1]],"date-time":"1997-04-01T00:00:00Z","timestamp":859852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1997,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To report a case of hypocalcemia and Hypomagnesemia after ibuprofen overdose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Summary<\/jats:title>\n                    <jats:p>A 21-month-old boy developed acute renal failure with severe metabolic acidosis after ingestion of ibuprofen 8 g. The infant developed tonic\u2013clonic seizures 46 hours after ingestion, with significant hypocalcemia and hypomagnesemia that required electrolyte replacement to control the seizures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>To our knowledge this is the first case report of hypocalcemia, hypomagnesemia, and seizures in a patient after ibuprofen overdose. The mechanism is unclear; the situation was probably aggravated by the use of sodium polystyrene sulfonate and furosemide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with ibuprofen overdose, serum calcium and magnesium concentrations should be evaluated since seizures may be associated with a deficiency of these cations. The management of these patients should include calcium and\/or magnesium supplementation when required and furosemide should be avoided.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/106002809703100408","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T06:13:15Z","timestamp":1496124795000},"page":"432-434","source":"Crossref","is-referenced-by-count":15,"title":["Hypocalcemia and Hypomagnesemia after Ibuprofen Overdose"],"prefix":"10.1177","volume":"31","author":[{"given":"Naffaa N","family":"Al-Harbi","sequence":"first","affiliation":[{"name":"College of Medicine, King Saud University\u2013Abha Branch, Abha, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somnuek","family":"Domrongkitchaiporn","sequence":"additional","affiliation":[{"name":"Nephrology Fellow, Division of Nephrology, Department of Pediatrics, B.C. Children's Hospital, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S","family":"Lirenman","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Pediatrics, B.C. Children's Hospital, Vancouver, British Columbia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,5,30]]},"reference":[{"key":"bibr1-106002809703100408","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(86)80617-5"},{"key":"bibr2-106002809703100408","first-page":"350","volume":"23","author":"Garreston L.K.","year":"1981","journal-title":"Vet Hum Toxicol"},{"key":"bibr3-106002809703100408","first-page":"1","volume":"3","author":"Court H.","year":"1984","journal-title":"Adverse Drug React Acute Poisoning Rev"},{"key":"bibr4-106002809703100408","doi-asserted-by":"publisher","DOI":"10.1177\/096032718300200234"},{"key":"bibr5-106002809703100408","doi-asserted-by":"publisher","DOI":"10.1007\/BF03259825"},{"key":"bibr6-106002809703100408","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198504000-00036"},{"key":"bibr7-106002809703100408","first-page":"747","volume":"110","author":"Lee C.Y.","year":"1986","journal-title":"Arch Pathol Lab Med"},{"key":"bibr8-106002809703100408","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198612000-00018"},{"key":"bibr9-106002809703100408","doi-asserted-by":"publisher","DOI":"10.1177\/106002809502900908"},{"key":"bibr10-106002809703100408","doi-asserted-by":"publisher","DOI":"10.1097\/00006565-199504000-00013"},{"key":"bibr11-106002809703100408","doi-asserted-by":"publisher","DOI":"10.3109\/15563659509000469"},{"key":"bibr12-106002809703100408","doi-asserted-by":"publisher","DOI":"10.3109\/15563659409017966"},{"key":"bibr13-106002809703100408","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1981.80"},{"key":"bibr14-106002809703100408","doi-asserted-by":"publisher","DOI":"10.3109\/00498257309151547"},{"key":"bibr15-106002809703100408","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.281.6253.1458-a"},{"key":"bibr16-106002809703100408","first-page":"1783","volume-title":"Nelson textbook of pediatrics.","author":"Behrman R.E.","year":"1992","edition":"14"},{"key":"bibr17-106002809703100408","first-page":"630","volume":"31","author":"Lee C.S.","year":"1983","journal-title":"Clin Res"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809703100408","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106002809703100408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:05:57Z","timestamp":1777374357000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/106002809703100408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,4]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,4]]}},"alternative-id":["10.1177\/106002809703100408"],"URL":"https:\/\/doi.org\/10.1177\/106002809703100408","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,4]]}}}