{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:26:19Z","timestamp":1787239579243,"version":"build-2736575974"},"reference-count":24,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[1997,9,1]],"date-time":"1997-09-01T00:00:00Z","timestamp":873072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[1997,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe two infants with cholestatic jaundice treated with ursodeoxycholic acid (UDCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Summary<\/jats:title>\n                    <jats:p>Two infants with cystic fibrosis (CF)-associated hepatobiliary disease, manifesting as cholestatic jaundice and elevated liver enzymes within the first 6 weeks of life, had improved biochemical indices of liver function following treatment with UDCA 20\u201340 mg\/kg\/d.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>To our knowledge, this is the first report of UDCA treatment in infants with CF-associated cholestatic jaundice. Infants and children require treatment with increased doses of UDCA to compensate for reduced intestinal absorption of bile acid and immaturity of the enterohepatic circulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>UDCA appears to be a cost-effective treatment for CF-associated hepatobiliary disease in infants and children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/106002809703100909","type":"journal-article","created":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T06:12:48Z","timestamp":1496124768000},"page":"1003-1005","source":"Crossref","is-referenced-by-count":14,"title":["Ursodeoxycholic Acid Improves Cholestasis in Infants with Cystic Fibrosis"],"prefix":"10.1177","volume":"31","author":[{"given":"Herschel","family":"Scher","sequence":"first","affiliation":[{"name":"Pediatric Allergy\/Pulmonary Division, Department of Pediatrics, College of Medicine, University of Iowa, Iowa City, IA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren P","family":"Bishop","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Division, Department of Pediatrics, College of Medicine, University of Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Paul B","family":"Mccray","sequence":"additional","affiliation":[{"name":"Pediatric Allergy\/Pulmonary Division, Department of Pediatrics, College of Medicine, University of Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,5,30]]},"reference":[{"key":"bibr1-106002809703100909","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(75)80351-9"},{"key":"bibr2-106002809703100909","doi-asserted-by":"publisher","DOI":"10.1136\/adc.46.250.805"},{"key":"bibr3-106002809703100909","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198802113180602"},{"key":"bibr4-106002809703100909","doi-asserted-by":"publisher","DOI":"10.1136\/adc.72.4.281"},{"key":"bibr5-106002809703100909","first-page":"1857","volume":"105","author":"Conn J.A.","year":"1993","journal-title":"Gut"},{"key":"bibr6-106002809703100909","first-page":"219","volume":"10","author":"Poupon R.E.","year":"1992","journal-title":"Prog Liver Dis"},{"key":"bibr7-106002809703100909","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70022-6"},{"key":"bibr8-106002809703100909","volume-title":"Package insert. 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Cholestatic liver diseases: new strategies for prevention and treatment of hepatobiliary and cholestatic liver disease. Proceedings of the 75th Falk Symposium, Maastricht, The Netherlands, April 22-23, 1994. 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