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In order to efficiently achieve system-level analyses (uncertainty propagation, sensitivity analysis, optimization, etc.), it is necessary to go beyond data set exchange which limits the capabilities of performance assessments. Multidisciplinary design optimization methodologies is a collection of engineering methodologies to optimize systems modelled as a set of coupled disciplinary analyses and is a key enabler to extend concurrent engineering capabilities. This article is focused on several examples of recent developments of multidisciplinary design optimization methodologies (e.g. multidisciplinary design optimization with transversal decomposition of the design process, multidisciplinary design optimization under uncertainty) with applications to launch vehicle design to illustrate the benefices of taking into account the coupling effects between the different physics all along the design process. These methods enable to manage the complexity of the involved physical phenomena and their interactions in order to generate innovative concepts such as reusable launch vehicles beyond existing solutions.<\/jats:p>","DOI":"10.1177\/1063293x17737131","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T04:39:45Z","timestamp":1509943185000},"page":"93-103","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Preliminary study on launch vehicle design: Applications of multidisciplinary design optimization methodologies"],"prefix":"10.1177","volume":"26","author":[{"given":"Lo\u00efc","family":"Brevault","sequence":"first","affiliation":[{"name":"ONERA\u2013The French Aerospace Lab, Palaiseau, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Balesdent","sequence":"additional","affiliation":[{"name":"ONERA\u2013The French Aerospace Lab, Palaiseau, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien","family":"Defoort","sequence":"additional","affiliation":[{"name":"ONERA\u2013The French Aerospace Lab, Palaiseau, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,11,6]]},"reference":[{"key":"bibr1-1063293X17737131","unstructured":"Allison J, Kokkolaras M, Zawislak M, et al. (2005) On the use of analytical target cascading and collaborative optimization for complex system design. In: 6th world congress on structural and multidisciplinary optimization, Rio de Janeiro, 30 May\u20133 June, pp. 3091\u20133100. Available at: http:\/\/systemdesign.illinois.edu\/publications\/All05a.pdf"},{"key":"bibr2-1063293X17737131","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-8920(01)00019-4"},{"key":"bibr3-1063293X17737131","doi-asserted-by":"publisher","DOI":"10.1137\/S1052623400378742"},{"key":"bibr4-1063293X17737131","volume-title":"Multidisciplinary design optimization of launch vehicles","author":"Balesdent M","year":"2011"},{"key":"bibr5-1063293X17737131","doi-asserted-by":"publisher","DOI":"10.2514\/1.52507"},{"key":"bibr6-1063293X17737131","doi-asserted-by":"publisher","DOI":"10.1007\/s00158-011-0701-4"},{"key":"bibr7-1063293X17737131","unstructured":"Balesdent M, Ordonneau G, Defoort S, et al. 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