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Due to the significant suitability of Multi-Agent Systems in building cyber-physical production systems compliant with the Reference Architectural Model Industry 4.0 (RAMI 4.0), more CPPS are being realized using Industrial Agents. Because of their complexity, guidelines for conducting virtual commissioning of agent-based CPPS are required. This paper proposes a novel framework for the virtual commissioning of agent-based CPPS. The framework contributions reside in incorporating both high-level and low-level control verification and validation (V&amp;V) and employing two combined SIL and HIL approaches during the virtual commissioning of agent-based CPPS. The feasibility of the framework was demonstrated during the V&amp;V of an agent-based CPPS on an industrial-scale laboratory robotized production cell. The framework had a significant impact on reducing the cost and efforts of the agent-based CPPS virtual commissioning.<\/jats:p>","DOI":"10.1177\/1063293x221121819","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T22:32:13Z","timestamp":1661207533000},"page":"399-410","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["A framework for an effective virtual commissioning of agent-based cyber-physical production systems integrated into manufacturing facilities"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0342-6192","authenticated-orcid":false,"given":"Abdelhamid","family":"Bendjelloul","sequence":"first","affiliation":[{"name":"CDTA, SRP Team, Center of Development of Advanced Technologies, Algiers, Algeria"},{"name":"LRPE Laboratory, USTHB University, Algiers, Algeria"}]},{"given":"Bachir","family":"Mihoubi","sequence":"additional","affiliation":[{"name":"CDTA, SRP Team, Center of Development of Advanced Technologies, Algiers, Algeria"}]},{"given":"Mehdi","family":"Gaham","sequence":"additional","affiliation":[{"name":"CDTA, SRP Team, Center of Development of Advanced Technologies, Algiers, Algeria"}]},{"given":"Mansour","family":"Moufid","sequence":"additional","affiliation":[{"name":"LRPE Laboratory, USTHB University, Algiers, Algeria"}]},{"given":"Brahim","family":"Bouzouia","sequence":"additional","affiliation":[{"name":"CDTA, SRP Team, Center of Development of Advanced Technologies, Algiers, Algeria"}]}],"member":"179","published-online":{"date-parts":[[2022,8,22]]},"reference":[{"key":"bibr1-1063293X221121819","unstructured":"Acatech WG (2013) \u2018Recommendations for Implementing the Strategic Initiative INDUSTRIE 4.0 - Final Report of the Industrie 4.0 Working Group\u2019. 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