{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:26:01Z","timestamp":1790886361719,"version":"4.1.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:p>Although clinically associated with von Hippel-Lindau (VHL) disease, the pathogenesis of papillary tumors of the broad ligament, epididymis, and peritoneum arising in patients with VHL disease is not clear. The \u201cclassic\u201d VHL-associated neoplasms, including hemangioblastoma and renal cell carcinoma, have been found to be associated with the inactivation of both VHL gene copies. It is not known whether a similar inactivation of the VHL gene is also responsible for the development of these uncommon VHL-associated lesions. The authors performed PCR (polymerase chain reaction) and PCR-based SSCP (single-strand conformation polymorphism) analysis on five predominantly papillary tumors in five VHL patients (one papillary cystadenoma of the broad ligament, one endometrioid cystadenoma of the broad ligament, two papillary cystadenomas of the epididymis, one papillary tumor of the retroperitoneum) with four polymorphic markers of VHL gene (D3S1038, D3S1110, D3S2452, 104\/105). All five tumors showed allelic loss of VHL gene. The results provide the first genetic evidence for the role of VHL gene in the tumorigenesis of these rare benign neoplasms and confirm these tumors as phenotypic manifestations of VHL disease.<\/jats:p>","DOI":"10.1177\/106689690000800308","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T21:50:28Z","timestamp":1182462628000},"page":"207-212","source":"Crossref","is-referenced-by-count":25,"title":["Allelic Deletion of VHL Gene Detected in Papillary Tumors of the Broad Ligament, Epididymis, and Retroperitoneum in von Hippel-Lindau Disease Patients"],"prefix":"10.1177","volume":"8","author":[{"given":"Ting","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengping","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborash J.","family":"Gersell","sequence":"additional","affiliation":[{"name":"Department of Pathology, the Washington University School of Medicine, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fattaneh A.","family":"Tavassoli","sequence":"additional","affiliation":[{"name":"Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2000,7,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(94)00391-H"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199711000-00001"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)49380-3"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1976.03630070017007"},{"key":"atypb5","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1056\/NEJM197801122980210","volume":"298","author":"Scully RE","year":"1978","journal-title":"N Engl J Med"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198802000-00008"},{"key":"atypb7","first-page":"527","volume":"153","author":"Funk KC","year":"1989","journal-title":"Am J Radiol"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)91207-S"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1038\/332268a0"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1126\/science.8493574"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1038\/327721a0"},{"key":"atypb12","first-page":"1071","volume":"51","author":"Anglard P","year":"1991","journal-title":"Cancer Res"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(97)90075-7"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870130303"},{"key":"atypb15","first-page":"951","volume":"13","author":"Vortmeyer AO","year":"1997","journal-title":"Am J Pathol"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65563-0"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.13.970-a"},{"key":"atypb18","first-page":"1437","volume":"45","author":"Knudson AG","year":"1985","journal-title":"Cancer Res"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199707000-00016"},{"key":"atypb20","first-page":"620","volume":"146","author":"Zhuang Z","year":"1995","journal-title":"Am J Pathol"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(95)90299-6"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1038\/ng0594-85"},{"key":"atypb23","first-page":"2089","volume":"149","author":"Lubensky IA","year":"1996","journal-title":"Am J Pathol"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106689690000800308","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106689690000800308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:21:44Z","timestamp":1777458104000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/106689690000800308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["10.1177\/106689690000800308"],"URL":"https:\/\/doi.org\/10.1177\/106689690000800308","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,7]]}}}