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The prognostic value of this genetic alteration in gastric carcinoma is far from being established. In the present study, formalin-fixed, paraffin-embedded gastric carcinoma tissues from 157 patients were evaluated for c-erb B-2 overexpression, by immunohistochemistry using a polyclonal antibody. c-erb B-2 expression was evaluated according to clinical and pathological parameters, and to the survival of the patients. Our results show that: (1) c-erb B-2 was overexpressed in 15.3% of gastric carcinoma cases; (2) c-erb B-2 overexpression was significantly more frequent in cardia (23.8%) and fundus\/body (25.0%) carcinomas than in antrum (7.2%) carcinomas; (3) c-erb B-2 overexpression was significantly associated with venous invasion; (4) c-erb B-2 is a prognostic factor for gastric carcinoma.<\/jats:p>","DOI":"10.1177\/106689690201000402","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T21:50:28Z","timestamp":1182462628000},"page":"247-256","source":"Crossref","is-referenced-by-count":41,"title":["c-erb B-2 Expression Is Associated with Tumor Location and Venous Invasion and Influences Survival of Patients with Gastric Carcinoma"],"prefix":"10.1177","volume":"10","author":[{"given":"Joao","family":"Pinto-de-Sousa","sequence":"first","affiliation":[{"name":"Surgery 4, Hospital S. 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