{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:35:47Z","timestamp":1778657747724,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:p>A 56-year-old man presented with fever, disorientation, and testicular pain. He was receiving azathioprine immunosuppression for autoimmune hepatitis. Orchiectomy identified occlusion of spermatic cord vessels by intravascular large B-cell lymphoma (IVLBL) and ischemic changes in the testis. Tumor cells were positive for CD 10, CD 20, CD 30, and Epstein-Barr virus (EBV) latent membrane protein 1 (LMP-1) and early region RNA (EBER). He was treated with the cessation of azathioprine, chemotherapy, anti-CD 20 immunotherapy, and radiotherapy. Twenty months after diagnosis, he is alive with no evidence of lymphoma or hepatitis. This is the first report of IVLBL presenting with testicular ischemia. It highlights the importance of prompt diagnosis and intervention to achieve durable response. That this lymphoma arose in the setting of immunosuppressive therapy introduces additional complexity relating to pathogenesis, clinical behavior, and treatment.<\/jats:p>","DOI":"10.1177\/106689690301100414","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T21:50:28Z","timestamp":1182462628000},"page":"319-324","source":"Crossref","is-referenced-by-count":19,"title":["Testicular Ischemia Due to Intravascular Large B-Cell Lymphoma: A Novel Presentation in an Immunosuppressed Individual"],"prefix":"10.1177","volume":"11","author":[{"given":"Paul","family":"Tranchida","sequence":"first","affiliation":[{"name":"Wayne State University School of Medicine, Detroit, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Bayerl","sequence":"additional","affiliation":[{"name":"Penn State University College of Medicine, Hershey, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Jo","family":"Voelpel","sequence":"additional","affiliation":[{"name":"Pontiac Osteopathic Hospital and Medical Center, Pontiac, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Palutke","sequence":"additional","affiliation":[{"name":"Wayne State University School of Medicine, Detroit, MI; Wayne State University School of Medicine, 3C University Health Center, 4201 Saint Antoine, Detroit, Michigan 48201"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,10,1]]},"reference":[{"key":"atypb1","first-page":"177","volume-title":"World Health Organization classification of tumours: Pathology and genetics of tumours of haematopoietic and lymphoid tissues","author":"Gatter KC","year":"2001"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880450"},{"key":"atypb3","first-page":"444","volume":"1","author":"Ferry JA","year":"1988","journal-title":"Mod Pathol"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.12.2573"},{"key":"atypb5","first-page":"91","volume":"8","author":"Wick MR","year":"1991","journal-title":"Semin Diagn Pathol"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930515)71:10<3156::AID-CNCR2820711043>3.0.CO;2-O"},{"key":"atypb7","first-page":"200","volume":"12","author":"Knowles DM","year":"1999","journal-title":"Mod Pathol"},{"key":"atypb8","unstructured":"8. 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