{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:10:51Z","timestamp":1787019051725,"version":"build-2736575974"},"reference-count":13,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:p>Ectopic adrenal cortical neoplasms are extremely rare, and only a few have involved the CNS. We report the first case of an intramedullary oncocytic adrenal cortical neoplasm of the spinal cord with immunohistochemical (IMHC) confirmation. A 27-year-old man presented with progressive lower extremity weakness, spastic paraparesis, decreased reflexes, and hypoesthesia below T10. A spinal myelogram showed cauda equina blockade and obliteration of sacral nerve roots. This prompted emergent surgical intervention. A well-circumscribed, approximately 3 \u00d7 2 cm, light brown to tan, intramedullary tumor was identified at the level of the conus medullaris. Histologically, the tumor showed sheets and nests of plump, cytologically bland polygonal cells with abundant eosinophilic cytoplasm. A single mitosis, but no necrosis, was identified. By IMHC, the cells were positive for inhibin, melan-A, and synaptophysin, and negative for GFAP, EMA, cytokeratins, S-100, HMB-45, and chromogranin. Electron microscopy study performed from paraffin-embedded tissues demonstrated abundant mitochondria, and lipid vacuoles. This case confirms the occurrence of adrenal cortical neoplasms in the CNS and is the first report of an intradural, intramedullary adrenal cortical adenoma of the spinal cord, and the first to occur in a male. This tumor should be considered in the differential diagnosis of tumors of the CNS.<\/jats:p>","DOI":"10.1177\/106689690401200309","type":"journal-article","created":{"date-parts":[[2006,3,31]],"date-time":"2006-03-31T17:39:14Z","timestamp":1143826754000},"page":"259-264","source":"Crossref","is-referenced-by-count":21,"title":["Spinal Adrenal Cortical Adenoma with Oncocytic Features: Report of the First Intramedullary Case and Review of the Literature"],"prefix":"10.1177","volume":"12","author":[{"given":"David S.","family":"Cassarino","sequence":"first","affiliation":[{"name":"Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariarita","family":"Santi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Washington Children\u2019s Hospital, Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaldo","family":"Arruda","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hospital Das Clinicas, Ceara Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regia","family":"Patrocinio","sequence":"additional","affiliation":[{"name":"Biopse Laboratories, Ceara, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Tsokos","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitya","family":"Ghatak","sequence":"additional","affiliation":[{"name":"Neuropathology and Autopsy Service, MCV Hospitals, Virginia Commonwealth University, Richmond, VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Quezado","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2004,7,1]]},"reference":[{"key":"atypb1","first-page":"190","volume":"16","author":"Baloch ZW","year":"1999","journal-title":"Semin Diagn Pathol"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19921201)70:11<2681::AID-CNCR2820701119>3.0.CO;2-H"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199304000-00024"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199005000-00008"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199704000-00002"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1986.tb02485.x"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1159\/000058430"},{"key":"atypb8","first-page":"310","volume":"94","author":"Kim SH","year":"2001","journal-title":"J Neurosurg"},{"key":"atypb9","first-page":"756","volume":"47","author":"Gelman BB","year":"2000","journal-title":"Neurosurg"},{"key":"atypb10","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1007\/BF01887014","volume":"282","author":"Hamperl H","year":"1931","journal-title":"Virchows Arch"},{"key":"atypb11","first-page":"91","volume":"16","author":"Giangaspero F","year":"1999","journal-title":"Semin Diagn Pathol"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880638"},{"key":"atypb13","first-page":"985","volume-title":"Enzinger and Weiss\u2019 Soft tissue tumors","author":"Weiss SW","year":"2001"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106689690401200309","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/106689690401200309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:17:57Z","timestamp":1777457877000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/106689690401200309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["10.1177\/106689690401200309"],"URL":"https:\/\/doi.org\/10.1177\/106689690401200309","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}