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Of these, 2 originated in the sigmoid colon, 1 in the cecum, 1 in the appendix, and 1 in the large bowel not otherwise specified. The tumors\u2019 size varied from 3 to 10 cm in the greatest diameter (mean 6.2 cm). Histologically they were composed of stellate or spindle shaped cells resembling fibroblasts arranged haphazardly or in intersecting fascicles, embedded in a collagen-rich stroma, with sparse intralesional mononuclear cells frequently arranged in lymphoid aggregates. Immunohistochemically, the lesions were positive for vimentin (7\/7), smooth muscle actin (8\/8), muscle-specific actin (5\/7), cytokeratins AE1\/AE3 (6\/7), and CAM 5.2 (1\/7), and antigen CD68 (1\/7). No case (0\/8) reacted positively with antibody to CD117 (c-kit). Genetically no substitutions, deletions, or insertions occurred in exon 11 in all analyzed samples. Likewise, no deletions or insertions in part of exon 9 were observed. Ultrastructurally the tumor cells revealed features typical of myofibroblasts. According to the morphologic, immunohistochemical, and ultrastructural features mentioned above, especially to the positivity of low-molecular-weight cytokeratins, we propose this lesion to be related to a proliferation of multipotential subserosal cells rather than ordinary myofibroblasts or fibroblasts.<\/jats:p>","DOI":"10.1177\/106689690401200409","type":"journal-article","created":{"date-parts":[[2006,4,4]],"date-time":"2006-04-04T14:30:54Z","timestamp":1144161054000},"page":"365-374","source":"Crossref","is-referenced-by-count":29,"title":["Reactive Nodular Fibrous Pseudotumors of the Gastrointestinal Tract: Report of 8 Cases"],"prefix":"10.1177","volume":"12","author":[{"given":"Ondrej","family":"Daum","sequence":"first","affiliation":[{"name":"Department of Pathology, Medical Faculty Hospital, Plzen, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Vanecek","sequence":"additional","affiliation":[{"name":"Department of Pathology, 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