{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:06:09Z","timestamp":1777716369781,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:p>To clarify the clinicopathologic and immunohistochemical features of reactive lymphoid hyperplasia with giant follicles (RHGF) among Japanese, 14 patients were studied. The subjects consisted of 9 males and 5 females, ranging in age from 9 to 61 years, with a mean age of 30 years and a median age of 24 years. None of the patients exhibited systemic symptoms. The affected lymph nodes were located in the head and neck area except in 1 case. At the time of lymph node biopsy, 1 patient was diagnosed as having acute infectious mononucleosis (IM) and 2 patients had a recent history of acute IM. One each with myelogenous leukemia or diffuse large B-cell lymphoma had a history of peripheral blood stem cell transplantation. There were no recurrences during follow-up periods ranging from 3 to 50 months. Histologically, 14 lesions were characterized by numerous enlarged, coalescing lymphoid follicles with distortion rather than effacement of the lymph node architecture. By in situ hybridization, Epstein-Barr virus (EBV) genomes were demonstrated in 5 (36%) of 14 cases. The present study indicates that a portion of RHGF appears to represent a histologic finding of acute IM. Moreover, as previously stated, RHGF should be differentiated from follicular lymphoma, particularly the floral variant.<\/jats:p>","DOI":"10.1177\/106689690501300306","type":"journal-article","created":{"date-parts":[[2006,3,31]],"date-time":"2006-03-31T17:39:14Z","timestamp":1143826754000},"page":"267-272","source":"Crossref","is-referenced-by-count":14,"title":["Reactive Lymphoid Hyperplasia of the Lymph Nodes with Giant Follicles: A Clinicopathologic Study of 14 Japanese Cases, with Special Reference to Epstein-Barr Virus Infection"],"prefix":"10.1177","volume":"13","author":[{"given":"Masaru","family":"Kojima","sequence":"first","affiliation":[{"name":"Department of Pathology and Clinical Laboratories, Gunma Cancer Center Hospital, Ohta, Department of Pathology, Dokkyo University School of Medicine, Mibu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Pathology and Clinical Laboratories, Nagoya University Hospital, Nagoya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Clinical Laboratories, Ashikaga Red Cross Hospital, Ashikaga"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misa","family":"Iijima","sequence":"additional","affiliation":[{"name":"Department of Pathology and Clinical Laboratories, Gunma Cancer Center Hospital, Ohta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayoko","family":"Murayama","sequence":"additional","affiliation":[{"name":"Department of Pathology and Clinical Laboratories, Gunma Cancer Center Hospital, Ohta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tone Central Hospital, Numata"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Clinical Laboratories, Maebashi Red Cross Hospital, Maebashi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Sakata","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fukuoka University School of Medicine, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhide","family":"Masawa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dokkyo University School of Medicine, Mibu"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,7,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(74)80005-5"},{"key":"atypb2","first-page":"553","volume-title":"The lymphoreticular system. 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