{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:06:38Z","timestamp":1777716398719,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p>We present a unique case of urothelial carcinoma of the right renal pelvis. It occurred in a 58-year-old woman. The tumor was located in the renal pelvis with extension into the adjacent renal medulla and cortex. Two years after surgical excision the patient is free of recurrence and metastasis. The tumor was well demarcated, without capsule, firm, solid, and whitish on the cut surface. It was 3 \u00d7 4 cm in largest diameter and without signs of necroses and hemorrhages. The tumor did not infiltrate the ureter. Histologically the predominant pattern of the tumor was adenocarcinomatous differentiation, and only very rare foci of urothelial carcinoma composed of typical transitional cells were found. No signs of intestinal type of metaplasia and adenocarcinoma, changes similar to the cystitis cystica or cystitis glandularis, were found in the tumor or in its vicinity. Most of the tumor looked like solid nests composed of cells with intracytoplasmic lumens. The resulting appearance was that of typical signetring cell change. These solid nests were usually surrounded by columnar epithelium, which in many areas formed papillary structures. A very striking feature was formation of collagen spherules. Small collagen spherules were often surrounded by a layer of the neoplastic cells so that collagenous rosettes were formed. In some areas these collagenous spherules clustered together so that they formed areas of collagenous spherulosis. The collagen in the spherules reacted positively with collagen IV. Ultrastructurally these spherules were formed by basal membrane-like material. Intracytoplasmic lumens of the signet-ring cell change were endowed by slender microvilli at ultrastructural level.<\/jats:p>","DOI":"10.1177\/106689690501300415","type":"journal-article","created":{"date-parts":[[2006,3,31]],"date-time":"2006-03-31T17:39:14Z","timestamp":1143826754000},"page":"375-378","source":"Crossref","is-referenced-by-count":14,"title":["Urothelial Signet-Ring Cell Carcinoma of the Renal Pelvis with Collagenous Spherulosis: A Case Report"],"prefix":"10.1177","volume":"13","author":[{"given":"Ond\u0159ej","family":"Hes","sequence":"first","affiliation":[{"name":"Department of Pathology, University Hospital Plzen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romuald","family":"\u010cu\u0159\u00edk","sequence":"additional","affiliation":[{"name":"Department of Pathology, Regional Hospital Ostrava, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karel","family":"Mainer","sequence":"additional","affiliation":[{"name":"Department of Urology, Regional Hospital Ostrava, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Michal","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital Plzen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,10,1]]},"reference":[{"key":"atypb1","first-page":"359","volume-title":"Pathology and genetics, tumours of the urinary system and male genital organs","author":"Eble JN","year":"2004"},{"key":"atypb2","unstructured":"Rosai J. 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