{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T08:07:23Z","timestamp":1778573243461,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p>\n                    Complete regression of high-grade lymphoma is extremely rare. We report 1 such case that might have been conceivably mediated by Ganoderma lucidum (Lingzhi), an immunomodulatory herbal medicine. A 47-year-old man presented with epigastric pain. Endoscopy revealed a large gastric ulcer, which on biopsy was diagnostic of large B-cell lymphoma. At gastrectomy 11 days later, no evidence was found of large B-cell lymphoma despite thorough sampling. Instead, there was a dense and permeative infiltrate of CD3\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    cytotoxic small T lymphocytes spanning the whole thickness of the gastric wall. In situ reverse transcription polymerase chain reaction for T-cell receptor \u03b2-chain family did not detect a monoclonal T-cell population. We postulate that the cytotoxic T cells may represent an active host\u2212immune response against the large B-cell lymphoma that resulted in a complete regression. On questioning, the patient had taken megadoses of Ganoderma lucidum, which might have triggered the successful immune reaction.\n                  <\/jats:p>","DOI":"10.1177\/1066896906295890","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T21:50:28Z","timestamp":1182462628000},"page":"180-186","source":"Crossref","is-referenced-by-count":15,"title":["Regression of Gastric Large B-Cell Lymphoma Accompanied by a Florid Lymphoma-like T-Cell Reaction: Immunomodulatory Effect of\n                    <i>Ganoderma lucidum<\/i>\n                    (Lingzhi)?"],"prefix":"10.1177","volume":"15","author":[{"given":"Wah","family":"Cheuk","sequence":"first","affiliation":[{"name":"Department of Pathology, Queen Elizabeth Hospital, Wylie Road, Kowloon, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John K. C.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Queen Elizabeth Hospital, Wylie Road, Kowloon, Hong Kong,."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard","family":"Nuovo","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Ohio State University, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"May K. M.","family":"Chan","sequence":"additional","affiliation":[{"name":"Hong Kong Sanatorium, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manson","family":"Fok","sequence":"additional","affiliation":[{"name":"Hong Kong Sanatorium, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,4,1]]},"reference":[{"key":"atypb1","first-page":"5","volume":"44","author":"Cole W.","year":"1976","journal-title":"Natl Cancer Inst Monogr"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830310215"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1177\/002215540104900201"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2004.01652.x"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-001-0446-z"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19871015)60:8<1872::AID-CNCR2820600833>3.0.CO;2-6"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1409"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90113-2"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.22.4245"},{"key":"atypb10","first-page":"1207","volume":"18","author":"Hiyama T.","year":"2001","journal-title":"Int J Oncol."},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.4.584"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.7.2041"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1007\/BF01541669"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.29.3611"},{"key":"atypb15","first-page":"2641","volume":"49","author":"Sone Y.","year":"1985","journal-title":"Agric Biol Chem"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970317)70:6<699::AID-IJC12>3.0.CO;2-5"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896906295890","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896906295890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:18:34Z","timestamp":1777457914000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1066896906295890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["10.1177\/1066896906295890"],"URL":"https:\/\/doi.org\/10.1177\/1066896906295890","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}