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In this article, the authors report on the comprehensive histopathologic, immunohistochemical, and molecular analysis of a case of primary testicular nasal-type natural killer\/T-cell lymphoma, and review the features of 16 previously reported patients. The investigation carried out in this study indicates that the testicular nasal-type natural killer\/T-cell lymphomas occur at a younger age than their B-cell counterparts, express cytoplasmic CD3 and surface CD56, and consistently show an infection by Epstein-Barr virus. These tumors have variable expression of T-cell antigens other than cytoplasmic CD3 and may show monoclonal rearrangement of T-cell receptor genes. Testicular natural killer\/T-cell lymphomas of nasal type invariably follow an aggressive clinical course.<\/jats:p>","DOI":"10.1177\/1066896907309687","type":"journal-article","created":{"date-parts":[[2008,6,23]],"date-time":"2008-06-23T02:17:37Z","timestamp":1214187457000},"page":"291-300","source":"Crossref","is-referenced-by-count":13,"title":["Histopathologic and Molecular Aspects of CD56+ Natural Killer\/ T-Cell Lymphoma of the Testis"],"prefix":"10.1177","volume":"16","author":[{"given":"Deborah L.","family":"Ornstein","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Yale University School of Medicine,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo B.","family":"Bifulco","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demetrios T.","family":"Braddock","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G.","family":"Howe","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Yale University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,4,2]]},"reference":[{"key":"atypb1","unstructured":"Chan J., Jaffe E., Ralfkiaer E. 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