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Histological examinations showed a submandibular gland exhibiting various degrees of atrophy with destruction of acini, infiltration by inflammatory cells, and periductal fibrosis. Reactions to cytokeratins (CKs) showed acini and duct remnants positive to CKs 7, 8, 19, and 13. CK14 stained myoepithelial cells around preserved acini and intercalated duct, and also basal cell of excretory ducts, but was negative in proliferating and branching ducts. Smooth muscle actin (SMA) was expressed by myofibroblasts in periductal fibrosis, and an intense expression of extracellular components was also seen. Lymphocyte markers showed, besides mature follicles, a higher presence of CD45RO positive cells. Thus, the immunoprofile of Kuttner is much more in keeping with an inflammatory-induced degenerative disease than with a preneoplastic lesion.<\/jats:p>","DOI":"10.1177\/1066896907309735","type":"journal-article","created":{"date-parts":[[2008,4,8]],"date-time":"2008-04-08T20:15:26Z","timestamp":1207685726000},"page":"143-149","source":"Crossref","is-referenced-by-count":9,"title":["Immunoprofile of Kuttner Tumor (Chronic Sclerosing Sialadenitis)"],"prefix":"10.1177","volume":"16","author":[{"given":"Suzana Orsini","family":"Machado de Sousa","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kivia","family":"Linhares Ferrazzo","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano","family":"Mota Loyola","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Federal University of Uberl\u00e2ndia, Uberl\u00e2ndia, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Nunes","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Federal University of Bahia, Salvador, Bahia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera Cavalcanti","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, S\u00e3o Leopoldo Mandic, Dental Research Institute, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,4,1]]},"reference":[{"key":"atypb1","volume-title":"Diseases of the Salivary","author":"Seifert G.","year":"1986"},{"key":"atypb2","first-page":"7","volume":"44","author":"Gallina E.","year":"1990","journal-title":"Acta Otorhinolaryngol Belg"},{"key":"atypb3","first-page":"81","volume":"25","author":"Seifert G.","year":"1977","journal-title":"HNO"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1997.2530856.x"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(11)80241-4"},{"key":"atypb6","unstructured":"Ellis GL, Auclair PL Atlas of Tumor Pathology: Tumors of the Salivary Gland. 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