{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:11:56Z","timestamp":1777716716895,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2008,9,14]],"date-time":"2008-09-14T00:00:00Z","timestamp":1221350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:p>This article reports the case of a 59-year-old patient with an 8-year history of chronic lymphocytic leukemia (CLL), prostate carcinoma, and squamous cell carcinoma who developed an ALK-positive anaplastic large cell lymphoma (ALCL). Lymph node and bone marrow biopsies showed 2 distinct morphologic populations: ( a) the CLL component showing a diffuse monomorphous infiltrate of small lymphocytes with the typical immunophenotype showing positive CD20, CD5, CD23, and \u03ba light chain restriction and ( b) the ALCL component showing large anaplastic pleomorphic cells positive for CD30, CD45, ALK, CD45Ro, CD4, and vimentin. Polymerase chain reaction performed on the lymph node for immunoglobulin heavy chain and T-cell receptor \u03b3 and \u03b2 showed gene rearrangements after macrodissection of morphologically distinct populations, indicating confirmed genetically distinct populations. Despite intensive chemotherapy, the patient died. This case represents the rare occurrence of an ALK-positive ALCL developing in a patient with CLL.<\/jats:p>","DOI":"10.1177\/1066896908324259","type":"journal-article","created":{"date-parts":[[2008,9,15]],"date-time":"2008-09-15T20:20:37Z","timestamp":1221510037000},"page":"424-428","source":"Crossref","is-referenced-by-count":10,"title":["ALK-Positive Anaplastic Large Cell Lymphoma in a Patient With Chronic Lymphocytic Leukemia"],"prefix":"10.1177","volume":"18","author":[{"family":"Ting Liu","sequence":"first","affiliation":[{"name":"Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, Department of Pathology, Huntsman Cancer Hospital, University of Utah, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Mai He","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane L.","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyrus","family":"Hedvat","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Teruya-Feldstein","sequence":"additional","affiliation":[{"name":"Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,9,14]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2291"},{"key":"atypb2","first-page":"304","volume":"9","author":"Harris NL","year":"1992","journal-title":"Semin Diagn Pathol"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1320-5463.2003.01455.x"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-004-0013-7"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2006.01.016"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31804bdaf8"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8652(200103)66:3<203::AID-AJH1045>3.0.CO;2-X"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.1190"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200407000-00002"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb14852.x"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/103.3.348"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/98.4.424"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/108.3.316"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403727"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.2000.00294.x"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.4.1425.h81602001425_1425_1429"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08226.x"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(98)80122-2"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896908324259","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896908324259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:19:38Z","timestamp":1777457978000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1066896908324259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,14]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["10.1177\/1066896908324259"],"URL":"https:\/\/doi.org\/10.1177\/1066896908324259","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,14]]}}}