{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T10:04:39Z","timestamp":1790157879252,"version":"4.1.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2009,1,4]],"date-time":"2009-01-04T00:00:00Z","timestamp":1231027200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:p>\n                    Aim. Sodium\/iodide symporter (NIS) is a transmembrane protein that mediates the transport of I\n                    <jats:sup>\u2212<\/jats:sup>\n                    . The aim was to evaluate the immunohistochemical expression of the human homolog of NIS (hNIS) in a wide spectrum of gastric lesions. Materials and methods. Seventy-seven samples were stained immunohistochemically with a monoclonal antibody for hNIS, including 14 with normal gastric mucosa, 14 with chronic atrophic gastritis with foveolar hyperplasia, 15 with chronic atrophic gastritis with intestinal metaplasia, 6 with chronic atrophic gastritis with atypical regenerative hyperplasia, 8 with chronic atrophic gastritis with dysplasia, 15 with invasive adenocarcinoma, 3 with well-differentiated neuroendocrine tumor, and 2 with gastrointestinal stromal tumors (GISTs). Results. hNIS stained the basolateral cytoplasmic portion of foveolae in normal mucosa, in 13 cases of chronic atrophic gastritis with foveolar hyperplasia, and in only 1 case of regenerative atypical hyperplasia. hNIS was consistently absent in intestinal metaplasia, in dysplastic glands, and in the cells constituting invasive carcinoma, well-differentiated neuroendocrine tumors, and GIST. Conclusion. It seems that lack of hNIS can be useful in distinguishing foveolar hyperplasia from dysplastic glands.\n                  <\/jats:p>","DOI":"10.1177\/1066896908329583","type":"journal-article","created":{"date-parts":[[2009,1,5]],"date-time":"2009-01-05T20:12:40Z","timestamp":1231186360000},"page":"327-334","source":"Crossref","is-referenced-by-count":3,"title":["Immunohistochemical Expression of the Human Sodium\/Iodide Symporter Distinguishes Malignant From Benign Gastric Lesions"],"prefix":"10.1177","volume":"17","author":[{"given":"Anna","family":"Farnedi","sequence":"first","affiliation":[{"name":"Section of Anatomic and Histopathology, Department of Haematology and Oncology, \u201cL. and A. Seragnoli\" University of Bologna, Bellaria Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo H.","family":"Eusebi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gastroenterology, University of Bologna Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Poli","sequence":"additional","affiliation":[{"name":"Section of Anatomic and Histopathology, Department of Haematology and Oncology, \u201cL. and A. Seragnoli\" University of Bologna, Bellaria Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria P.","family":"Foschini","sequence":"additional","affiliation":[{"name":"Section of Anatomic and Histopathology, Department of Haematology and Oncology, \u201cL. and A. Seragnoli\" University of Bologna, Bellaria Hospital,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,1,4]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-7-5"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1038\/379458a0"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.1358"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345302"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1210\/endo.138.8.5262"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.83.5.4839"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1630495"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.10.6329"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021544"},{"key":"atypb10","first-page":"4178","volume":"84","author":"Spitzweg C.","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"atypb11","volume-title":"Gastrointestinal Pathology","author":"Fenoglio-Preiser CM","year":"2008"},{"key":"atypb12","volume-title":"Pathology and Genetics of Tumours of the Digestive System","author":"Hamilton SR","year":"2000"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1410382"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1998.00570.x"},{"key":"atypb15","first-page":"11","volume":"4","author":"Venturi S.","year":"2000","journal-title":"Adv Clin Path"},{"key":"atypb16","doi-asserted-by":"crossref","first-page":"921","DOI":"10.26719\/2004.10.6.921","volume":"10","author":"Behrouzian R.","year":"2004","journal-title":"East Mediterr Health J"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896908329583","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896908329583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:19:14Z","timestamp":1777457954000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1066896908329583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,4]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["10.1177\/1066896908329583"],"URL":"https:\/\/doi.org\/10.1177\/1066896908329583","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,4]]}}}