{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:14:47Z","timestamp":1791486887785,"version":"4.3.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2009,2,17]],"date-time":"2009-02-17T00:00:00Z","timestamp":1234828800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p>Mediastinal diffuse large B-cell lymphoma (Med-DLBCL) is a subtype of DLBCL that has morphologic and clinical similarities and phenotypic overlaps with classical Hodgkin lymphoma (CHL) involving the mediastinum. CD23 is a marker that has been previously reported in Med-DLBCI and is proposed in the differential diagnosis of M-DLBCL and CHL. A panel of immunostains, including CD45, CD20, CD3, CD30, CD15, CD21, and CD23 as well as Eber was performed on Med-DLBCL and 20CHL. 23\/27 Med-DLBCL (85%) were positive for CD23 (membranous) CD30 was negative in 6 and positive in 21 cases. 18 CHL cases were negative for CD23 and only 2 showed rare scattered Reed\u2014Sternberg cells with weak cytoplasmic CD23 staining. CD23 showed a sensitivity of 85% and positive predictive value of 92%. In conclusion CD23 is a useful marker in distinguishing Med-DLBCL and CHL in mediastinal biopsies and may be helpful as an adjunct to histomorphology and other markers in the diagnosis and appropriate clinical management of these lesions.<\/jats:p>","DOI":"10.1177\/1066896909331994","type":"journal-article","created":{"date-parts":[[2009,2,17]],"date-time":"2009-02-17T22:08:35Z","timestamp":1234908515000},"page":"121-128","source":"Crossref","is-referenced-by-count":30,"title":["The Value of CD23 Expression as an Additional Marker in Distinguishing Mediastinal (Thymic) Large B-Cell Lymphoma From Hodgkin Lymphoma"],"prefix":"10.1177","volume":"18","author":[{"given":"Mohamed E.","family":"Salama","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rajan Mariappan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Division of Matrix Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kedar","family":"Inamdar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Henry Ford Hospital, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheryl R.","family":"Tripp","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherrie L.","family":"Perkins","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,2,17]]},"reference":[{"key":"atypb1","unstructured":"Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. 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