{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:04:01Z","timestamp":1777716241110,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2009,4,15]],"date-time":"2009-04-15T00:00:00Z","timestamp":1239753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>The simultaneous diagnosis of marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) and chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL) is rare. This study reports a patient with composite synchronous biclonal occurrence of MALT lymphoma of the lung and CLL\/SLL. The morphology of the lung and peripheral blood showed features of MALT lymphoma and CLL, respectively. The cytogenetic evaluation of the lung specimen revealed a t(1;14) (p22;q32), a frequent genetic abnormality in MALT lymphoma. Flow cytometry analysis of the lung tissue showed features of MALT lymphoma and CLL\/SLL with different light chain restriction, whereas the blood showed phenotypic evidence of CLL\/SLL. Fluorescence in situ hybridization study of the blood showed a deletion of 13q14 and 17p13. Immunoglobulin heavy chain (IgH) gene rearrangement study of the lung tissue and blood showed a monoclonal IgH gene rearrangement with distinct light chain restriction, suggesting that the immunophenotypically different cell populations originated from separate clones.<\/jats:p>","DOI":"10.1177\/1066896909332454","type":"journal-article","created":{"date-parts":[[2009,4,16]],"date-time":"2009-04-16T20:12:55Z","timestamp":1239912775000},"page":"377-381","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Composite Biclonal Marginal Zone Lymphoma of Lung and Chronic Lymphocytic Leukemia: Pathologic, Phenotypic, Cytogenetic, and Molecular Study"],"prefix":"10.1177","volume":"19","author":[{"given":"Sharathkumar","family":"Bhagavathi","sequence":"first","affiliation":[{"name":"Department of Pathology, Indiana University, Indianapolis, Indiana (S Bhagavathi), , Department of Pathology, William Beaumont Hospital, Royal Oak, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Micale","sequence":"additional","affiliation":[{"name":"William Beaumont Hospital, Royal Oak, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vonda","family":"Douglas-Nikitin","sequence":"additional","affiliation":[{"name":"William Beaumont Hospital, Royal Oak, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer","family":"Ballouz","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, William Beaumont Hospital, Royal Oak, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Neumann","sequence":"additional","affiliation":[{"name":"William Beaumont Hospital, Royal Oak, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann Marie","family":"Blenc","sequence":"additional","affiliation":[{"name":"William Beaumont Hospital, Royal Oak, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,4,15]]},"reference":[{"key":"atypb1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2008","edition":"4"},{"key":"atypb2","unstructured":"Rai KR Chronic lymphocytic leukemia. In: Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, eds. Hematology: Basic Principles and Practice. London, UK: Churchill Livingstone; 1991:990-1001."},{"key":"atypb3","first-page":"338","volume":"26","author":"Yuen A.","year":"1999","journal-title":"Semin Oncol"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65443-0"},{"key":"atypb5","first-page":"176","volume":"114","author":"Duque RE","year":"1990","journal-title":"Arch Pathol Lab Med."},{"key":"atypb6","volume-title":"t(1;14)(p22;q32) in non Hodgkin\u2019s lymphoma (NHL)","author":"Cuneo A.","year":"2001"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80957-5"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1007\/s001090050350"},{"issue":"2","key":"atypb9","first-page":"S19","volume":"11","author":"D\u00f6hner H.","year":"1997","journal-title":"Leukemia"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.6.1580.bloodjournal8561580"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1080\/10428190500138039"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07923.x"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896909332454","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896909332454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:17:46Z","timestamp":1777457866000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1066896909332454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,15]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["10.1177\/1066896909332454"],"URL":"https:\/\/doi.org\/10.1177\/1066896909332454","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,15]]}}}