{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:03:26Z","timestamp":1777716206176,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2009,8,10]],"date-time":"2009-08-10T00:00:00Z","timestamp":1249862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p>Primary Hodgkin\u2019s lymphoma (HL) of the stomach is an extremely rare entity. Most cases of gastric involvement by HL are observed in the setting of disseminated disease. The nonspecific nature of the symptoms and endoscopic findings, which include a large malignant-looking ulcer and mass or wall thickening, together with the considerable histological overlap between HLs and some non-HLs or undifferentiated carcinoma, make the surgical resection diagnosis extremely difficult. An accurate diagnosis is important as treatment and outcome differ significantly for these neoplasms. In small endoscopic gastric biopsies and even in postoperative specimens, the precise histological diagnosis of HL is particularly challenging. Here, the authors report 5 cases of 2 women and 3 men aged 22 to 68, with gastric involvement by classic HLs\u20143 primary gastric HLs and 2 as part of widespread disease. All 5 patients presented with digestive symptoms. At endoscopy, the lesions presented as ulcerated and elevated lesions, with or without mucosal thickening. Four patients were misdiagnosed in the preoperative biopsy or in the gastrectomy specimen. Association with Epstein-Barr virus (EBV) was detected in 4 cases, with a predominance of subtype A EBV. These cases illustrate the significant difficulties, both clinical and pathological, in achieving the diagnosis of HL involving the stomach in immunocompetent patients.<\/jats:p>","DOI":"10.1177\/1066896909341799","type":"journal-article","created":{"date-parts":[[2009,8,10]],"date-time":"2009-08-10T20:24:55Z","timestamp":1249935895000},"page":"235-240","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Hodgkin\u2019s Lymphoma Presenting as Dominant Gastric Lesion in Immunocompetent Patients: Report of 5 Cases With EBV Analysis"],"prefix":"10.1177","volume":"19","author":[{"given":"Gabriela","family":"Gualco","sequence":"first","affiliation":[{"name":"Consultoria em Patologia, Botucatu, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Ortega","sequence":"additional","affiliation":[{"name":"Armed Forces Central Hospital, Montevideo, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucimara","family":"Chioato","sequence":"additional","affiliation":[{"name":"Consultoria em Patologia, Botucatu, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria L.","family":"Musto","sequence":"additional","affiliation":[{"name":"Armed Forces Central Hospital, Montevideo, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livia M.","family":"Bacchi","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence M.","family":"Weiss","sequence":"additional","affiliation":[{"name":"the Division of Pathology at the City of Hope National Medical Center, Duarte, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos E.","family":"Bacchi","sequence":"additional","affiliation":[{"name":"Consultoria em Patologia, Botucatu, S\u00e3o Paulo, Brazil,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,8,10]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1998.00316.x-i1"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1159\/000226009"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/95.6.794"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.1997.tb02020.x"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(05)81766-0"},{"key":"atypb6","first-page":"697","volume":"66","author":"Castellino RA","year":"1982","journal-title":"Cancer Treat Rep"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/89.6.806"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830215)51:4<701::AID-CNCR2820510425>3.0.CO;2-D"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900915)66:6<1283::AID-CNCR2820660631>3.0.CO;2-4"},{"key":"atypb10","volume-title":"World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2008"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18004921319"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1080\/10428190400012037"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-5-119"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.06094"},{"key":"atypb15","first-page":"63","volume":"9","author":"Bacchi M.","year":"1996","journal-title":"Mod Pathol"},{"key":"atypb16","first-page":"595","volume":"12","author":"Howe JR","year":"1997","journal-title":"Histol Histopathol"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403202"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-006-0244-z"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1177\/030089169207800414"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1007\/BF01211383"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-78-1-113"},{"key":"atypb22","first-page":"271","volume":"8","author":"Morrison P.","year":"1982","journal-title":"Clin Oncol"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.5858\/2002-126-1534-PGIHL"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06444.x"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200001000-00008"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199401000-00005"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-000-0094-9"},{"key":"atypb28","first-page":"1595","volume":"83","author":"Gulley M.","year":"1994","journal-title":"American ethnicity. 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