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Microscopically, the neoplasm consisted of well-demarcated islets, some of them cystically dilated. The architecture of islets varied from solid to cribriform and micropapillary without comedo-type necroses. The tumor cells featured no significant cytologic atypia. Immunohistochemically, luminal cells showed expression of cytokeratins (CK), CK7, CK18, and S100 protein. In addition, immunostains for CK5\/6, CK14, p63 protein, and smooth muscle actin displayed a continuous rim of myoepithelial cells around all tumor nests. In contrast, detection of CK20, hormonal receptors (androgen, estrogen, and progesterone), epidermal growth factor receptor and Her-2\/neu oncoprotein was negative. The patient is free of disease for 2 years. The relationship between low-grade cribriform cystadenocarcinoma and salivary duct carcinoma is discussed.<\/jats:p>","DOI":"10.1177\/1066896910367649","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T08:46:03Z","timestamp":1499762763000},"page":"369-373","source":"Crossref","is-referenced-by-count":26,"title":["Low-Grade Cribriform Cystadenocarcinoma of the Parotid Gland: A Neoplasm With Favorable Prognosis, Distinct From Salivary Duct Carcinoma"],"prefix":"10.1177","volume":"18","author":[{"given":"Jan","family":"Laco","sequence":"first","affiliation":[{"name":"The Fingerland Department of Pathology, Charles University Faculty of Medicine and Faculty Hospital in Hradec Kralove, Czech Republic,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslav","family":"Podhola","sequence":"additional","affiliation":[{"name":"The Fingerland Department of Pathology, Charles University Faculty of Medicine and Faculty Hospital in Hradec Kralove, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Dolezalova","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Charles University Faculty of Medicine and Faculty Hospital in Hradec Kralove, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,10,1]]},"reference":[{"key":"atypb1","first-page":"233","author":"Brandwein-Gensler MS","year":"2005","journal-title":"Pathology and Genetics. 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