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The development of prostatic carcinoma in situ or invasive small cell carcinoma (SCC) of the prostate has not been previously reported in a patient with this syndrome. In this report, an 87-year-old White man with the Lynch syndrome had a prostate biopsy that revealed a mixed high-grade conventional adenocarcinoma and SCC of the prostate with high-grade prostatic intraepithelial neoplasia of the small cell neuroendocrine-type (HGPIN-NE), all showing MSH2 microsatellite instability and loss of MSH2 expression, a finding not previously published. These findings suggest that HGPIN-NE is a precursor of invasive SCC and also that prostatic SCC can develop in a patient with the Lynch syndrome.<\/jats:p>","DOI":"10.1177\/1066896910379406","type":"journal-article","created":{"date-parts":[[2010,8,26]],"date-time":"2010-08-26T20:40:16Z","timestamp":1282855216000},"page":"550-553","source":"Crossref","is-referenced-by-count":11,"title":["Neuroendocrine-Type Prostatic Adenocarcinoma With Microsatellite Instability in a Patient With Lynch Syndrome"],"prefix":"10.1177","volume":"18","author":[{"given":"David G.","family":"Wagner","sequence":"first","affiliation":[{"name":"University of Nebraska Medical Center, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoran","family":"Gatalica","sequence":"additional","affiliation":[{"name":"Creighton University Medical Center, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry T.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Creighton University Medical Center, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shane","family":"Kohl","sequence":"additional","affiliation":[{"name":"Methodist Hospital, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonny L.","family":"Johansson","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subodh M.","family":"Lele","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center, Omaha, NE, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,8,25]]},"reference":[{"key":"atypb1","unstructured":"Peltomaki P., Vasen H., Jass JR Hereditary nonpolyposis colorectal cancer. 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