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Material from 68 patients (35.1%) represented PNI. PNI was significantly correlated with advanced tumor stage ( P &lt; .001). Patients with deep cervical stromal invasion (&gt;66%) showed more PNI than those with more superficial invasion (41% vs 16.9%; P = .001). Tumors with spray-like PI showed significantly more PNI (48.4%) when compared with finger-like PI (26.7%) and those with pushing borders (18.8%; P = .007). Strong peritumoral desmoplastic stromal reaction and absence of peritumoral inflammation were associated with a higher frequency of PNI ( P &lt; .001). PNI is associated with advanced tumor stage, deep cervical stromal invasion (&gt;66%), high grade of tumor cell dissociation (ie, spray-like pattern of invasion), strong peritumoral desmoplastic stromal reaction, and reduced peritumoral inflammation.<\/jats:p>","DOI":"10.1177\/1066896910381898","type":"journal-article","created":{"date-parts":[[2011,4,7]],"date-time":"2011-04-07T09:59:36Z","timestamp":1302170376000},"page":"159-163","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Morphological Parameters Associated With Perineural Invasion (PNI) in Carcinoma of the Cervix Uteri"],"prefix":"10.1177","volume":"19","author":[{"given":"Alexandra","family":"Meinel","sequence":"first","affiliation":[{"name":"University of Leipzig, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uta","family":"Fischer","sequence":"additional","affiliation":[{"name":"University of Leipzig, 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