{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:41:23Z","timestamp":1785404483797,"version":"3.56.0"},"reference-count":57,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:p>Abnormal substances in the nuclei that can be observed by light microscopy are often broadly referred to as nuclear inclusions. Although their recognition in the appropriate clinicopathological settings can aid in the diagnosis of some disease entities and tumor types, they can also be a source of error. There are 2 morphologically distinct types of inclusions with different mechanisms of formation and diagnostic significance, including bona fide nuclear inclusions and nuclear pseudoinclusions. Bona fide nuclear inclusions result from accumulation in the nuclei of viral particles, cytoplasmic materials (such as surfactant, immunoglobulin, and glycogen), biotin, nuclear lamins, or polyglutamine. Some of them are diagnostically helpful, such as surfactant inclusion, which can support the pulmonary origin of an adenocarcinoma, whereas others may be misleading, such as biotin inclusion, which can be mistaken for herpes infection. Nuclear pseudoinclusions, which represent invaginations of cytoplasm into the nucleus, are delimited by the nuclear membrane. Although not totally specific, they are particularly common in papillary thyroid carcinoma, meningioma, and usual ductal hyperplasia of the breast and hence may aid in the diagnosis of these entities. Nuclear pseudo-pseudoinclusions, which are artefactual bubbles in the nuclei that mimic nuclear pseudoinclusions or clear nuclei, can lead to misdiagnosis of follicular adenoma or hyperplastic nodule as papillary thyroid carcinoma.<\/jats:p>","DOI":"10.1177\/1066896910385342","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T02:59:15Z","timestamp":1499741955000},"page":"465-481","source":"Crossref","is-referenced-by-count":41,"title":["Nuclear Inclusions and Pseudoinclusions: Friends or Foes of the Surgical Pathologist?"],"prefix":"10.1177","volume":"18","author":[{"given":"Yiu-Tung","family":"Ip","sequence":"first","affiliation":[{"name":"Queen Elizabeth Hospital, Hong Kong, Hong Kong, SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Antonio","family":"Dias Filho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Anatomia, Belo Horizonte, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K. C.","family":"Chan","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital, Hong Kong, Hong Kong, SAR China,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,12,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196607)19:7<1026::AID-CNCR2820190718>3.0.CO;2-#"},{"key":"atypb2","first-page":"124","volume":"14","author":"Ng AB","year":"1970","journal-title":"Acta Cytol"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90274-7"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31816a32fc"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1159\/000326143"},{"key":"atypb6","volume-title":"Diagnostic Pathology of Infectious Diseases","author":"Kradin R.","year":"2010"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90230-M"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2006.02460.x"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000176427.99004.d7"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000051680.14007.D7"},{"key":"atypb11","doi-asserted-by":"crossref","first-page":"536","DOI":"10.5858\/2006-130-536-CHSVLA","volume":"130","author":"Pilichowska ME","year":"2006","journal-title":"Arch Pathol Lab Med"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800179"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1995.tb03420.x"},{"key":"atypb14","first-page":"178","volume":"116","author":"Krause JR","year":"1992","journal-title":"Arch Pathol Lab Med"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410180412"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.36.4.499"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711570208"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3935-0_32"},{"key":"atypb19","first-page":"873","volume":"38","author":"Aiba M.","year":"1988","journal-title":"Acta Pathol Jpn"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/22.5.887"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/66.1.10"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90066-3"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(90)90076-H"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19921215)70:12<2923::AID-CNCR2820701232>3.0.CO;2-G"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2004.03.018"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(11)80919-2"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711760411"},{"key":"atypb28","first-page":"831","volume":"118","author":"Sickel JZ","year":"1994","journal-title":"Arch Pathol Lab Med"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000092953.20717.48"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/99.1.13"},{"key":"atypb31","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/S0344-0338(11)81140-4","volume":"191","author":"Chan JK","year":"1995","journal-title":"Pathol Res Pract"},{"key":"atypb32","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/S0344-0338(11)81141-6","volume":"191","author":"Matias-Guiu X.","year":"1995","journal-title":"Pathol Res Pract"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1998.0415a.x"},{"key":"atypb34","first-page":"400","volume":"12","author":"Cameselle-Teijeiro J.","year":"1999","journal-title":"Mod Pathol"},{"key":"atypb35","first-page":"945","volume":"11","author":"Tanaka Y.","year":"1998","journal-title":"Mod Pathol"},{"key":"atypb36","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199406000-00008"},{"key":"atypb37","doi-asserted-by":"publisher","DOI":"10.1159\/000326588"},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.5858\/2005-129-1288-GCTVOE"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199903000-00014"},{"key":"atypb40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02911.x"},{"key":"atypb41","first-page":"431","volume":"88","author":"Leestma JE","year":"1969","journal-title":"Arch Pathol"},{"key":"atypb42","first-page":"781","volume":"21","author":"Okamoto K.","year":"1981","journal-title":"Rinsho Shinkeigaku"},{"key":"atypb43","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)64029-7"},{"key":"atypb44","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0720889.x"},{"key":"atypb45","doi-asserted-by":"publisher","DOI":"10.1042\/bse0330149"},{"key":"atypb46","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/1.4.255"},{"key":"atypb47","doi-asserted-by":"publisher","DOI":"10.1080\/14734220510007950"},{"key":"atypb48","volume-title":"Intra-operative diagnosis of CNS tumours","author":"Moss TH","year":"1997"},{"key":"atypb49","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198610000-00002"},{"key":"atypb50","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198708000-00001"},{"key":"atypb51","volume-title":"Problems in Breast Pathology","author":"Azzopardi JG","year":"1979"},{"key":"atypb52","volume-title":"Pathology of the Breast","author":"Tavassoli FA","year":"1999","edition":"2"},{"key":"atypb53","volume-title":"Biopsy Interpretation of the Breast","author":"Schnitt SJ","year":"2009"},{"key":"atypb54","volume-title":"Diagnostic Problems in Breast Pathology","author":"Koerner FC","year":"2009"},{"key":"atypb55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2006.02451.x"},{"key":"atypb56","unstructured":"Lewis SE Hematoxylin and eosin. In: Brown RW, ed. Histologic Preparations: Common Problems and Their Solutions. Northfield, IL: CAP Press; 2009:35-47."},{"key":"atypb57","unstructured":"Chan JKC Tumors of the thyroid and parathyroid glands . In: Fletcher CDM, ed. Diagnostic Histopathology of Tumors. 3rd ed. Philadelphia, PA: Elsevier; 2007:997-1079."}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896910385342","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896910385342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:17:32Z","timestamp":1777457852000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1066896910385342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":57,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["10.1177\/1066896910385342"],"URL":"https:\/\/doi.org\/10.1177\/1066896910385342","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}