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End-stage kidney specimens from 61 patients (47 males and 14 females) with 109 renal-cell carcinomas were selected. Papillary renal-cell carcinoma was the most common malignancy (61\/109, 56%), followed by CCPC (20\/109, 18%). The CCPC showed a papillary or tubular\/solid architecture, clear cytoplasm, low nuclear grade, and a distinct immunohistochemical profile (RCC\u2212, vimentin+, CK7+, p504S\u2212). ACDAC displayed a variety of architectural patterns, eosinophilic cytoplasm, high nuclear grade, intratumoral calcium oxalate deposits, and an immunohistochemical profile similar to type 2 papillary renal-cell carcinoma (RCC+, vimentin+, CK7\u2212\/+, p504S+). Less than 5% (3\/69) of pathologically staged renal-cell carcinomas in end-stage kidneys presented with lymphogenous and\/or hematogenous metastases.<\/jats:p>","DOI":"10.1177\/1066896911414273","type":"journal-article","created":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T20:39:30Z","timestamp":1311712770000},"page":"19-28","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":63,"title":["Renal-Cell Carcinomas in End-Stage Kidneys"],"prefix":"10.1177","volume":"20","author":[{"given":"Ramneesh","family":"Bhatnagar","sequence":"first","affiliation":[{"name":"University of Maryland Medical Center, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borislav A.","family":"Alexiev","sequence":"additional","affiliation":[{"name":"University of Maryland Medical Center, Baltimore, MD, 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