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Plasma cell granuloma preferentially involves the lung, with only 18 cases of thyroid gland involvement having been reported to date in the English literature. Thyroid plasma cell granuloma preferentially affects women and classically shows a prominent plasma cell infiltrate embedded in a variable degree of fibrous stroma: only 2 of the reported cases exhibited the morphologic features of inflammatory myofibroblastic tumor. These morphologic features may raise problems in the differential diagnosis with other plasma cell\u2013rich disorders, including infectious diseases and auto(dys)immune conditions, including the recently described \u201cIgG4-related sclerosing disease.\u201d In view of these considerations, a contemporary diagnostic approach to thyroid plasma cell granuloma is therefore discussed here.<\/jats:p>","DOI":"10.1177\/1066896911431453","type":"journal-article","created":{"date-parts":[[2011,12,17]],"date-time":"2011-12-17T20:23:22Z","timestamp":1324153402000},"page":"500-506","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Plasma Cell Granuloma of the Thyroid Gland"],"prefix":"10.1177","volume":"20","author":[{"given":"Anna","family":"Cremonini","sequence":"first","affiliation":[{"name":"San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurilio","family":"Ponzoni","sequence":"additional","affiliation":[{"name":"San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Beretta","sequence":"additional","affiliation":[{"name":"San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilberto","family":"Mari","sequence":"additional","affiliation":[{"name":"San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Giulia","family":"Cangi","sequence":"additional","affiliation":[{"name":"San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluigi","family":"Arrigoni","sequence":"additional","affiliation":[{"name":"San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Doglioni","sequence":"additional","affiliation":[{"name":"San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,12,16]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"284","volume-title":"Enzinger and Weiss\u2019s Soft Tissue Tumors","author":"Weiss SW","year":"2008","unstructured":"Weiss SW, Goldblum JR. 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