{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:10:50Z","timestamp":1777716650299,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2012,6,25]],"date-time":"2012-06-25T00:00:00Z","timestamp":1340582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>Dedifferentiated chondrosarcomas (DDCS) account for approximately 10% of all chondrosarcoma cases and its 5-year survival is only 10%. The dedifferentiated components of DDCS could be osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma. In this article, the authors report a rare case of DDCS in a 19-year-old female, in which the dedifferentiated component showed a close histological resemblance to a giant cell tumor of bone. Radiological diagnosis revealed an expansive osteolytic lesion in the epiphysis of right proximal humerus, which also extended to the diaphysis with irregular calcification and focal cortical breakthrough. The biopsy tissue contained the features of a giant cell tumor of bone and well-differentiated cartilage. Pathological examination revealed a biphasic tumor comprising of low-grade chondrosarcoma and nonchondroid giant cell\u2013rich lesion similar to conventional giant cell tumor of bone, and there is an abrupt transition between the 2 components.<\/jats:p>","DOI":"10.1177\/1066896912451322","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T11:18:15Z","timestamp":1340795895000},"page":"48-53","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Benign Looking Giant Cell Component in Dedifferentiated Chondrosarcoma"],"prefix":"10.1177","volume":"21","author":[{"given":"Jin","family":"Huang","sequence":"first","affiliation":[{"name":"Shanghai Sixth People\u2019s Hospital, Shanghai Jiaotong University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiming","family":"Jiang","sequence":"additional","affiliation":[{"name":"Shanghai Sixth People\u2019s Hospital, Shanghai Jiaotong University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingcheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai Sixth People\u2019s Hospital, Shanghai Jiaotong University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huizhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Sixth People\u2019s Hospital, Shanghai Jiaotong University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,6,25]]},"reference":[{"key":"bibr1-1066896912451322","first-page":"252","volume-title":"World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Soft Tissue and Bone","author":"Milchgrub S","year":"2002"},{"key":"bibr2-1066896912451322","first-page":"71","volume-title":"Dahlin\u2019s Bone Tumors: General Aspects and Data on 11,087 Cases","author":"Unni KK","year":"1996","edition":"5"},{"key":"bibr3-1066896912451322","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197108)28:2<461::AID-CNCR2820280227>3.0.CO;2-U"},{"key":"bibr4-1066896912451322","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21936"},{"key":"bibr5-1066896912451322","doi-asserted-by":"publisher","DOI":"10.1053\/adpa.2002.33905"},{"key":"bibr6-1066896912451322","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.43763"},{"key":"bibr7-1066896912451322","first-page":"820","volume":"38","author":"Huang J","year":"2009","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"bibr8-1066896912451322","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199603000-00005"},{"key":"bibr9-1066896912451322","doi-asserted-by":"publisher","DOI":"10.1080\/003130299104873"},{"key":"bibr10-1066896912451322","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.029629"},{"key":"bibr11-1066896912451322","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-008-0567-0"},{"key":"bibr12-1066896912451322","unstructured":"Mirra JM. 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