{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:11:02Z","timestamp":1777716662788,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T00:00:00Z","timestamp":1345766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>The goal of this study was to assess the pathological and differential diagnoses of sinonasal teratocarcinosarcoma (SNTCS) in order to ultimately improve the diagnosis and treatment of this rare disease. Data from 2 cases of sinonasal teratocarcinosarcoma from the Wuxi People\u2019s Hospital (China) were analyzed. The clinical presentation for these patients consisted of nasal obstruction, epistaxis, and headache. On further physical examination, the presence of a polypoid mass was identified and, despite surgery and radiotherapy, both cases experienced recurrence. Histologically, the tumors showed a heterogeneous mixture of components from the 3 germ layers, primitive neuroepithelial elements, diagnostic immature squamous cell nests (clear cell nests), and various epithelial and mesenchymal components. Staining of the different germ layers corresponded with the appropriate immune markers. In case 1, the postradiotherapy resection specimen was completely dominated by a mature teratoma, with a complete absence of the corresponding adenocarcinoma and fibrosarcoma components. To date, this is the first study describing this composition within an SNTCS recurrent tumor. In summary, SNTCS is a rare tumor characterized by the presence of benign and malignant epithelial, mesenchymal, and dysembryomal components. Owing to its heterogeneous histologic appearance, adequate sampling and recognition of all SNTCS components are needed for future diagnosis. Currently, surgical removal, postoperative radiotherapy, and a histology-specific multidrug chemotherapy appear to be the best therapeutic approach. Future individualized therapy may also hold promise.<\/jats:p>","DOI":"10.1177\/1066896912457202","type":"journal-article","created":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T22:01:42Z","timestamp":1345845702000},"page":"37-43","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Sinonasal Teratocarcinosarcoma"],"prefix":"10.1177","volume":"21","author":[{"given":"Shudong","family":"Yang","sequence":"first","affiliation":[{"name":"Wuxi People\u2019s Hospital, Nanjing Medical University, Wuxi, Jiangsu, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongchao","family":"Sun","sequence":"additional","affiliation":[{"name":"Wuxi People\u2019s Hospital, Nanjing Medical University, Wuxi, Jiangsu, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiabei","family":"Liang","sequence":"additional","affiliation":[{"name":"Wuxi People\u2019s Hospital, Nanjing Medical University, Wuxi, Jiangsu, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Wuxi People\u2019s Hospital, Nanjing Medical University, Wuxi, Jiangsu, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Wuxi People\u2019s Hospital, Nanjing Medical University, Wuxi, Jiangsu, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Rui","sequence":"additional","affiliation":[{"name":"Wuxi People\u2019s Hospital, Nanjing Medical University, Wuxi, Jiangsu, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,8,24]]},"reference":[{"key":"bibr1-1066896912457202","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.6.592"},{"key":"bibr2-1066896912457202","doi-asserted-by":"publisher","DOI":"10.1258\/00222150360600986"},{"key":"bibr3-1066896912457202","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0463.2000.d01-96.x"},{"key":"bibr4-1066896912457202","doi-asserted-by":"publisher","DOI":"10.2310\/7070.2005.34421"},{"key":"bibr5-1066896912457202","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840515)53:10<2140::AID-CNCR2820531025>3.0.CO;2-Y"},{"key":"bibr6-1066896912457202","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-008-0094-x"},{"key":"bibr7-1066896912457202","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2007.05.003"},{"key":"bibr8-1066896912457202","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2011.02733.x"},{"key":"bibr9-1066896912457202","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2009.02.022"},{"key":"bibr10-1066896912457202","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0014-1"},{"key":"bibr11-1066896912457202","doi-asserted-by":"publisher","DOI":"10.2310\/7070.2004.03012"},{"key":"bibr12-1066896912457202","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(01)00575-4"},{"key":"bibr13-1066896912457202","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20139"},{"key":"bibr14-1066896912457202","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2006.03.006"},{"key":"bibr15-1066896912457202","doi-asserted-by":"publisher","DOI":"10.1080\/01913120050118602"},{"key":"bibr16-1066896912457202","first-page":"76","volume-title":"World Health Organization Classification of Tumours. 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