{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:11:13Z","timestamp":1777716673422,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,12,5]],"date-time":"2012-12-05T00:00:00Z","timestamp":1354665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>Dedifferentiated epithelial\u2013myoepithelial carcinoma (DEMC) is very rare salivary gland neoplasm with only anecdotal reports. We present an analysis of DEMC, based on a case and review of literature. Our patient, an 85-year-old woman, presented with a submandibular mass of 5 years duration that was increasing in size over a 5-week period. Histologically, there were areas of typical epithelial\u2013myoepithelial carcinoma, with dedifferentiation of both components, manifesting morphologically as salivary duct carcinoma and areas of myoepithelial carcinoma. A review of literature revealed 21 previously reported cases of DEMC. DEMC occurs at an average age of 72 years, most often in the parotid gland (72%) followed by submandibular gland (17%). Dedifferentiation more often involves the epithelial component (13\/15 cases) than the myoepithelial component (5\/15 cases). Although typical epithelial\u2013myoepithelial carcinomas are fairly indolent (average disease-free survival of 11.34 years), dedifferentiation confers a poor prognosis (survival reported from 1 to 72 months).<\/jats:p>","DOI":"10.1177\/1066896912468153","type":"journal-article","created":{"date-parts":[[2012,12,5]],"date-time":"2012-12-05T21:30:17Z","timestamp":1354743017000},"page":"514-519","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Dedifferentiated Epithelial\u2013Myoepithelial Carcinoma"],"prefix":"10.1177","volume":"21","author":[{"given":"Aaron R.","family":"Baker","sequence":"first","affiliation":[{"name":"Penn State College of Medicine & Penn State Milton S. Hershey Medical Center, Hershey, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara E.","family":"Ohanessian","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine & Penn State Milton S. Hershey Medical Center, Hershey, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eelam","family":"Adil","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine & Penn State Milton S. Hershey Medical Center, Hershey, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry S.","family":"Crist","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine & Penn State Milton S. Hershey Medical Center, Hershey, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Goldenberg","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine & Penn State Milton S. Hershey Medical Center, Hershey, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haresh","family":"Mani","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine & Penn State Milton S. 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