{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:12:53Z","timestamp":1777716773876,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T00:00:00Z","timestamp":1379462400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>Malignant mesothelioma is a primary neoplasm of the serosal membranes that usually presents with a diffuse pattern of growth. However, cases of localized mesotheliomas have been described. The predominant localization is the pleura; peritoneum and pericardium being rarer localizations. Only few cases of true intraparenchymal mesothelioma arising in organs such as liver, gonads, lung, and pancreas have been described. We report a case of an otherwise healthy 48-year-old man without asbestos exposure with a nodule of 3 cm in diameter, localized in the spleen, discovered incidentally at the ultrasonographic examination, for which histopathological and immunohistochemical findings were consistent with epithelioid mesothelioma: large round cells with eosinophil dense cytoplasm and macronucleoli and with immunohistochemical positivity for pancytokeratins, calretinin, Wilms tumor-1, and others markers of mesothelial differentiation. The diagnosis of localized intrasplenic epithelioid malignant mesothelioma was carried out. To the best of our knowledge, this is the first case of a localized intrasplenic mesothelioma published in the indexed literature.<\/jats:p>","DOI":"10.1177\/1066896913503492","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T23:34:21Z","timestamp":1379633661000},"page":"451-455","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Localized Intrasplenic Mesothelioma"],"prefix":"10.1177","volume":"22","author":[{"given":"Michele","family":"Giansanti","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine, Section of Pathology, Medical School, University of Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Bellezza","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Section of Pathology, Medical School, University of Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Guerriero","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Section of Pathology, Medical School, University of Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjuta","family":"Pireddu","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Section of Pathology, Medical School, University of Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Sidoni","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Section of Pathology, Medical School, University of Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,9,18]]},"reference":[{"key":"bibr1-1066896913503492","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000165529.78945.dc"},{"key":"bibr2-1066896913503492","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2008.02217.x"},{"key":"bibr3-1066896913503492","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.615"},{"key":"bibr4-1066896913503492","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-010-0885-9"},{"key":"bibr5-1066896913503492","doi-asserted-by":"publisher","DOI":"10.1007\/BF00429358"},{"key":"bibr6-1066896913503492","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.00942.x"},{"key":"bibr7-1066896913503492","volume":"304","author":"Roggli VL.","year":"1981","journal-title":"N Engl J Med"},{"key":"bibr8-1066896913503492","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199507000-00010"},{"key":"bibr9-1066896913503492","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)41262-2"},{"key":"bibr10-1066896913503492","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.09.008"},{"key":"bibr11-1066896913503492","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.32.672"},{"key":"bibr12-1066896913503492","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930100502"},{"key":"bibr13-1066896913503492","first-page":"52","volume":"46","author":"Metser U","year":"2005","journal-title":"J Nucl Med"},{"key":"bibr14-1066896913503492","doi-asserted-by":"publisher","DOI":"10.5858\/2007-131-965-SMCPDD"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896913503492","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1066896913503492","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896913503492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:19:57Z","timestamp":1777457997000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1066896913503492"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2013,9,18]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1177\/1066896913503492"],"URL":"https:\/\/doi.org\/10.1177\/1066896913503492","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,18]]}}}