{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T17:18:39Z","timestamp":1780939119313,"version":"3.54.1"},"reference-count":5,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T00:00:00Z","timestamp":1393545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>Although Paget disease of the nipple (PDN) is a well-established clinical and pathological neoplastic process, invasive PDN (IPDN) is a relatively newly described disease. The latter entity is characterized by invasive carcinoma that is localized to the nipple and is associated with PDN as well as with either intraductal and\/or invasive carcinoma in the underlying breast. To our knowledge, only 17 cases of IPDN, all node negative, have been reported. Here, we report the case of a 68-year-old woman with invasive Paget disease of the left nipple. The patient had a history of intraductal carcinoma, treated by lumpectomy alone. She presented 6 years later with \u201ceczematous\u201d lesion of the ipsilateral nipple, a punch biopsy of which showed a superficially IPDN as well as conventional PDN. The subsequently performed wide excision of the nipple, areola, and underlying breast tissue showed the invasive carcinoma to span 0.6 cm. Then, 3 months later, the patient presented with ipsilateral palpable axillary lymphadenopathy. Axillary dissection revealed metastatic carcinoma in 7 of 19 lymph nodes. This case of IPDN not only represents the deepest extent of invasion reported thus far but also the only one known to be node positive.<\/jats:p>","DOI":"10.1177\/1066896914525229","type":"journal-article","created":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:50:29Z","timestamp":1393635029000},"page":"566-569","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Invasive Paget Disease of the Nipple"],"prefix":"10.1177","volume":"22","author":[{"given":"Ugur","family":"Ozerdem","sequence":"first","affiliation":[{"name":"Weill Cornell Medical College, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Swistel","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian B.","family":"Antonio","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed A.","family":"Hoda","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,2,28]]},"reference":[{"key":"bibr1-1066896914525229","first-page":"621","volume-title":"Rosen\u2019s Breast Pathology","author":"Rosen PP","year":"2009","edition":"3"},{"key":"bibr2-1066896914525229","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318259ef7f"},{"key":"bibr3-1066896914525229","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2011-0611-OA"},{"key":"bibr4-1066896914525229","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4741.2003.09317.x"},{"key":"bibr5-1066896914525229","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181fd1eec"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896914525229","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1066896914525229","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896914525229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:20:08Z","timestamp":1777458008000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1066896914525229"}},"subtitle":["A Brief Review of the Literature and Report of the First Case With Axillary Nodal Metastases"],"short-title":[],"issued":{"date-parts":[[2014,2,28]]},"references-count":5,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1177\/1066896914525229"],"URL":"https:\/\/doi.org\/10.1177\/1066896914525229","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,28]]}}}