{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:18:02Z","timestamp":1777717082277,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T00:00:00Z","timestamp":1469664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>We report a case of a 53-year-old woman who presented with rectal bleeding and a 9.5 cm hemicircumferential ascending colon mass. Histology revealed adenosquamous carcinoma (ASC), a rare subtype comprised of malignant squamous and glandular elements. Immunohistochemistry revealed loss of MLH1\/PMS2 expression and retained MSH2\/MSH6 expression in squamous and glandular components, indicative of microsatellite instability (MSI). MSI is caused by loss-of-function defects in DNA mismatch repair genes, leading to increased susceptibility to a variety of neoplasms; the role of MSI in colorectal ASC is unknown. The tumor was negative for MLH1 gene promoter hypermethylation, the patient had a germline MLH1 mutation, and met criteria for Lynch syndrome. To our knowledge this is the first report of a MSI-high colorectal carcinoma (CRC) showing adenosquamous histology. Further evaluation of MSI status in colorectal ASC may be warranted as this may be another histologic type of CRC associated with MSI.<\/jats:p>","DOI":"10.1177\/1066896916659539","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T20:37:40Z","timestamp":1468615060000},"page":"653-655","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Primary Colon Adenosquamous Carcinoma in a Patient With Lynch Syndrome"],"prefix":"10.1177","volume":"24","author":[{"given":"Virginia E.","family":"Duncan","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuko","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd M.","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,7,28]]},"reference":[{"key":"bibr1-1066896916659539","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2011.11.001"},{"key":"bibr2-1066896916659539","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e3182420953"},{"key":"bibr3-1066896916659539","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh034"},{"key":"bibr4-1066896916659539","doi-asserted-by":"publisher","DOI":"10.4174\/jkss.2011.80.Suppl1.S31"},{"key":"bibr5-1066896916659539","doi-asserted-by":"publisher","DOI":"10.3393\/ac.2013.29.2.83"},{"key":"bibr6-1066896916659539","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2000.01105.x"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896916659539","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1066896916659539","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896916659539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:21:13Z","timestamp":1777458073000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1066896916659539"}},"subtitle":["A New Histologic Subtype Associated With Microsatellite Instability?"],"short-title":[],"issued":{"date-parts":[[2016,7,28]]},"references-count":6,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1177\/1066896916659539"],"URL":"https:\/\/doi.org\/10.1177\/1066896916659539","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,28]]}}}