{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:26:50Z","timestamp":1785320810883,"version":"3.55.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T00:00:00Z","timestamp":1479859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>Background. Nasopharyngeal carcinoma (NPC) is highly associated with Epstein-Barr virus (EBV), particularly the undifferentiated nonkeratinizing subtype. Prevalence of EBV in NPC in countries such as Guatemala and Brazil has not been studied. Methods. We analyzed 19 cases of NPC, 11 from Guatemala and 8 from Brazil, for the presence of EBV by in situ hybridization and immunohistochemistry. Additionally, 19 hyperplastic adenoids from children were analyzed for EBV by in situ hybridization, 12 from Guatemala and 7 from Brazil. Results. All the NPC cases from Guatemala and 5 from Brazil were of the undifferentiated nonkeratinizing type. EBV-negative cases comprised 2 keratinizing NPC and 1 differentiated nonkeratinizing NPC. All undifferentiated nonkeratinizing NPC from both samples showed intense positivity for EBER, while LMP-1 only focally and scarcely expressed. EBER was positive in 75% and 43% of the adenoids from Guatemala and Brazil, respectively. Conclusions. All undifferentiated nonkeratinizing NPC irrespective of origin from Guatemala or Brazil were highly associated with EBV.<\/jats:p>","DOI":"10.1177\/1066896916679518","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T21:31:06Z","timestamp":1479936666000},"page":"304-309","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Epstein-Barr Virus in Nasopharyngeal Carcinoma of Guatemalan and Brazilian Patients"],"prefix":"10.1177","volume":"25","author":[{"given":"Alicia","family":"Rumayor Pi\u00f1a","sequence":"first","affiliation":[{"name":"University of Campinas (UNICAMP), Piracicaba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harim Tavares","family":"dos Santos","sequence":"additional","affiliation":[{"name":"University of Campinas (UNICAMP), Piracicaba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Carlos","sequence":"additional","affiliation":[{"name":"Centro Cl\u00ednico de Cabeza y Cuello\/Hospital Herrera Llerandi, Ciudad de Guatemala, Guatemala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albina","family":"Altemani","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical Sciences Faculty, University of Campinas (UNICAMP), Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oslei Paes","family":"de Almeida","sequence":"additional","affiliation":[{"name":"University of Campinas (UNICAMP), Piracicaba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,11,23]]},"reference":[{"key":"bibr1-1066896916679518","first-page":"85","volume-title":"World Health Organization Classification of Tumours. Pathology & Genetics\u2014Head and Neck Tumors","volume":"2005","author":"Chan JKC"},{"key":"bibr2-1066896916679518","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0353"},{"key":"bibr3-1066896916679518","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711650105"},{"key":"bibr4-1066896916679518","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199807)55:3<227::AID-JMV8>3.0.CO;2-3"},{"key":"bibr5-1066896916679518","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(95)90195-7"},{"key":"bibr6-1066896916679518","doi-asserted-by":"publisher","DOI":"10.1136\/mp.48.6.M322"},{"key":"bibr7-1066896916679518","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980801)83:3<582::AID-CNCR29>3.0.CO;2-R"},{"key":"bibr8-1066896916679518","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181d9ba21"},{"key":"bibr9-1066896916679518","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113702"},{"key":"bibr10-1066896916679518","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5131(03)01160-9"},{"key":"bibr11-1066896916679518","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800369"},{"key":"bibr12-1066896916679518","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2006.044586"},{"key":"bibr13-1066896916679518","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2011.06.012"},{"key":"bibr14-1066896916679518","first-page":"549","volume":"33","author":"Tsang CM","year":"2014","journal-title":"Chin J Cancer"},{"key":"bibr15-1066896916679518","first-page":"1","volume-title":"Nasopharyngeal Cancer","volume":"2010","author":"Ma J"},{"key":"bibr16-1066896916679518","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000217243.08756.0c"},{"key":"bibr17-1066896916679518","doi-asserted-by":"publisher","DOI":"10.1006\/scbi.1996.0023"},{"key":"bibr18-1066896916679518","doi-asserted-by":"publisher","DOI":"10.5732\/cjc.010.10377"},{"key":"bibr19-1066896916679518","doi-asserted-by":"publisher","DOI":"10.1053\/ajot.2001.28071"},{"key":"bibr20-1066896916679518","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2011.12.007"},{"key":"bibr21-1066896916679518","doi-asserted-by":"publisher","DOI":"10.1002\/path.4448"},{"key":"bibr22-1066896916679518","doi-asserted-by":"publisher","DOI":"10.1309\/MMAU-0QYH-7BHA-W8C2"},{"key":"bibr23-1066896916679518","volume-title":"Epstein-Barr Virus and Kaposi\u2019s Sarcoma Herpesvirus\/Human Herpesvirus 8","author":"International Agency for Research on Cancer; World Health Organization","year":"1997"},{"key":"bibr24-1066896916679518","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2003.00040.x"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896916679518","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1066896916679518","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896916679518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:21:26Z","timestamp":1777458086000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1066896916679518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,23]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1177\/1066896916679518"],"URL":"https:\/\/doi.org\/10.1177\/1066896916679518","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,23]]}}}