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Histopathological examination of the resected specimen showed a heterogeneous, high-grade mesenchymal nonlipogenic tumor with areas of osteoblastic\/osteosarcomatous differentiation and aneurysmal bone cyst\u2013like features. Based on the clinical presentation, the morphology, and the supportive immunohistochemical and molecular findings (MDM2 overexpression and amplification of the MDM2 gene, respectively), a diagnosis of a dedifferentiated liposarcoma with heterologous osteosarcomatous differentiation and an aneurysmal bone cyst\u2013like morphology was made. To the best of our knowledge, this is the first description of aneurysmal bone cyst\u2013like morphology in dedifferentiated liposarcoma, further expanding the broad morphological spectrum of dedifferentiated liposarcoma.<\/jats:p>","DOI":"10.1177\/1066896917693093","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T03:52:10Z","timestamp":1487044330000},"page":"374-378","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Dedifferentiated Liposarcoma of the Retroperitoneum With Heterologous Osteosarcomatous Differentiation and a Striking Aneurysmal Bone Cyst\u2013Like Morphology"],"prefix":"10.1177","volume":"25","author":[{"given":"Carole","family":"Van Haverbeke","sequence":"first","affiliation":[{"name":"Ghent University Hospital, Ghent University, Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo","family":"Van Dorpe","sequence":"additional","affiliation":[{"name":"Ghent University Hospital, Ghent University, Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyne","family":"Lecoutere","sequence":"additional","affiliation":[{"name":"Ghent University Hospital, Ghent University, Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uta","family":"Flucke","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liesbeth","family":"Ferdinande","sequence":"additional","affiliation":[{"name":"Ghent University Hospital, Ghent University, Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Creytens","sequence":"additional","affiliation":[{"name":"Ghent University Hospital, Ghent University, Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,2,14]]},"reference":[{"key":"bibr1-1066896917693093","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197108)28:2<461::AID-CNCR2820280227>3.0.CO;2-U"},{"key":"bibr2-1066896917693093","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-197912000-00004"},{"key":"bibr3-1066896917693093","first-page":"37","volume-title":"World Health Organization Classification of Tumours; Pathology and Genetics. 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