{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:20:28Z","timestamp":1777717228386,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T00:00:00Z","timestamp":1492992000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Special Account for Research of the University of Crete","award":["KA3200"],"award-info":[{"award-number":["KA3200"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Background. Protein kinase C \u03b2II promotes melanogenesis and affects proliferation of melanocytic cells but is frequently absent or decreased in melanoma cells in vitro. Objective. To investigate PKC-\u03b2II expression and spatial distribution within a lesion in various benign and malignant melanocytic proliferations. Methods. Expression of PKC-\u03b2II was semiquantitatively assessed in the various existing compartments (intraepidermal [not nested], junctional [nested], and dermal) of benign (n = 43) and malignant (n = 28) melanocytic lesions by immunohistochemistry. Results. Melanocytes in the basal layer of normal skin or in lentigo simplex stained strongly for PKC-\u03b2II. Common nevi lacked completely PKC-\u03b2II. All other lesions expressed variably PKC-\u03b2II, with cutaneous melanoma metastases displaying the lowest rate of positivity (14%). In the topographical analysis within a lesion, PKC-\u03b2II expression was largely retained in the intraepidermal and junctional part of all other lesions (dysplastic nevus, lentigo maligna, and melanoma). Reduced expression of PKC-\u03b2II was found in the dermal component of benign and malignant lesions ( P = .041 vs intraepidermal). PKC-\u03b2II expression in the various compartments did not differ significantly between benign and malignant lesions. Conclusions. The current study revealed a significant correlation between PKC-\u03b2II expression and spatial localization of melanocytes, with the lowest expression found in the dermal compartment and the highest in the epidermal compartment.<\/jats:p>","DOI":"10.1177\/1066896917706026","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T07:19:40Z","timestamp":1493018380000},"page":"497-501","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Topography of Protein Kinase C \u03b2II in Benign and Malignant Melanocytic Lesions"],"prefix":"10.1177","volume":"25","author":[{"given":"Konstanin","family":"Krasagakis","sequence":"first","affiliation":[{"name":"Laboratory of Dermatology, Division of Internal Medicine, University of Crete, Heraklion, 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