{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:21:00Z","timestamp":1777717260003,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T00:00:00Z","timestamp":1497398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>Primary central nervous system T-cell lymphoma (PCNSTCL) is rare, accounting for 2% of CNS lymphomas. We report the first case of PCNSTCL with aberrant expression of CD20 and CD79a in an 81-year-old man with a left periventricular brain mass. A biopsy revealed dense lymphoid infiltrate consisting of medium-sized cells in a background of gliosis and many histiocytes. The lymphoid cells were positive for CD2, CD3, CD7, CD8, T-cell intracellular antigen-1, granzyme B, CD20, and CD79a and negative for CD4, CD5, PAX-5, OCT-2, BOB-1, human herpes virus-8, and Epstein-Barr virus\u2013encoded small RNAs. Molecular studies revealed clonal TCR-\u03b2 and TCR-\u03b3 gene rearrangements and negative immunoglobulin gene rearrangements. The patient was treated with chemotherapy (vincristine and methotrexate) and rituximab, but he died 1 month after the diagnosis. This is a unique case that emphasizes the use of a multimodal approach, including a broad immunohistochemical panel and molecular studies in lineage determination for lymphomas with ambiguous phenotype.<\/jats:p>","DOI":"10.1177\/1066896917714325","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T05:33:50Z","timestamp":1497418430000},"page":"599-603","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Primary Central Nervous System T-Cell Lymphoma With Aberrant Expression of CD20 and CD79a: A Diagnostic Pitfall"],"prefix":"10.1177","volume":"25","author":[{"given":"Neha","family":"Gupta","sequence":"first","affiliation":[{"name":"Hofstra Northwell School of Medicine, Lake Success, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansoor","family":"Nasim","sequence":"additional","affiliation":[{"name":"Hofstra Northwell School of Medicine, Lake Success, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia G.","family":"Spitzer","sequence":"additional","affiliation":[{"name":"Hofstra Northwell School of Medicine, Lake Success, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinmin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hofstra Northwell School of Medicine, Lake Success, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,6,14]]},"reference":[{"key":"bibr1-1066896917714325","first-page":"240","volume-title":"World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of the Haematopoietic and Lymphoid Tissues","author":"Kluin PM","year":"2008"},{"key":"bibr2-1066896917714325","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.07.109"},{"key":"bibr3-1066896917714325","doi-asserted-by":"publisher","DOI":"10.1080\/10428190802311441"},{"key":"bibr4-1066896917714325","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880133"},{"key":"bibr5-1066896917714325","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31817d7452"},{"key":"bibr6-1066896917714325","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880265"},{"key":"bibr7-1066896917714325","first-page":"1831","volume":"2013","author":"Matnani RG","year":"2013","journal-title":"Case Rep Hematol"},{"key":"bibr8-1066896917714325","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000503"},{"key":"bibr9-1066896917714325","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2015.10.017"},{"key":"bibr10-1066896917714325","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16532"},{"key":"bibr11-1066896917714325","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199411000-00003"},{"key":"bibr12-1066896917714325","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12427"},{"key":"bibr13-1066896917714325","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.4.1453.bloodjournal8641453"},{"key":"bibr14-1066896917714325","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.990140212"},{"key":"bibr15-1066896917714325","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/106.1.78"},{"key":"bibr16-1066896917714325","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400118"},{"key":"bibr17-1066896917714325","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.09.131"},{"key":"bibr18-1066896917714325","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14473"},{"key":"bibr19-1066896917714325","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw248"},{"key":"bibr20-1066896917714325","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-015-1841-x"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896917714325","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1066896917714325","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896917714325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:21:41Z","timestamp":1777458101000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1066896917714325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,14]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1177\/1066896917714325"],"URL":"https:\/\/doi.org\/10.1177\/1066896917714325","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,14]]}}}