{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T10:23:13Z","timestamp":1777717393818,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T00:00:00Z","timestamp":1515542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>A collision tumor is defined as two histologically distinct tumor types identified at the same anatomic site. Hematolymphoid proliferative disorders (HLPDs), which coincide with non-hematological neoplasms, can mimic an immune response and can easily be overlooked as an immune reaction to a solid organ neoplasm, especially when low grade. In order to avoid a delay in the diagnosis of a HLPD during the workup for a non-hematological neoplasm, we identified a cohort of 100 cases with a HLPD diagnosis during the initial workup and treatment of a non-hematological neoplasm, or vice versa. Among the 100 collision tumors, the most common non-hematological neoplasms associated with a HLPD were from the colon (17%), breast (15%), and prostate (12%). The most commonly identified HLPDs were chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL; 18%), diffuse large B-cell lymphoma (17%), follicular lymphoma (14%), marginal zone lymphoma (10%), acute myeloid leukemia (8%), and classical Hodgkin lymphoma (5%). Interestingly, in this cohort 5% of the low-grade HLPDs, all of them CLL\/SLL, were missed at initial sign-out and subsequently required an addendum report. The other 95% of cases were reviewed or signed out by a hematopathologist before the report was finalized for the non-hematological neoplasm. In summary, high-grade hematological malignancies are less likely to be missed; however, low-grade coexisting HLPDs can be overlooked as a reactive immune response to a solid organ neoplasm. Therefore, it is important to keep in mind the existence of collision low-grade HLPDs before assuming the lymphoid infiltrates as an immunological response.<\/jats:p>","DOI":"10.1177\/1066896917752862","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T02:10:58Z","timestamp":1515723058000},"page":"296-305","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Did I Miss It? Discovering Hidden Coexisting Hematological Neoplasms: A Single Institutional Review of 100 Collision Tumors"],"prefix":"10.1177","volume":"26","author":[{"given":"Evan","family":"Himchak","sequence":"first","affiliation":[{"name":"Montefiore Medical Center\/Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etan","family":"Marks","sequence":"additional","affiliation":[{"name":"Montefiore Medical Center\/Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Shi","sequence":"additional","affiliation":[{"name":"Montefiore Medical Center\/Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7946-2843","authenticated-orcid":false,"given":"Yanhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Montefiore Medical Center\/Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,1,10]]},"reference":[{"key":"bibr1-1066896917752862","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2015.10.003"},{"key":"bibr2-1066896917752862","first-page":"313","volume":"29","author":"Whipham T.","year":"1878","journal-title":"Trans Pathol Soc London"},{"key":"bibr3-1066896917752862","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V12.9.788.788"},{"key":"bibr4-1066896917752862","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20616"},{"key":"bibr5-1066896917752862","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.56.12.970"},{"key":"bibr6-1066896917752862","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-12-147"},{"key":"bibr7-1066896917752862","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.4310"},{"key":"bibr8-1066896917752862","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i11.1850"},{"key":"bibr9-1066896917752862","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20176"},{"key":"bibr10-1066896917752862","doi-asserted-by":"publisher","DOI":"10.1177\/1066896915582263"},{"key":"bibr11-1066896917752862","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.13.6.483"},{"key":"bibr12-1066896917752862","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.1998"},{"key":"bibr13-1066896917752862","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2017","edition":"4"},{"key":"bibr14-1066896917752862","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198801143180203"},{"key":"bibr15-1066896917752862","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03610.x"},{"key":"bibr16-1066896917752862","volume-title":"WHO Classification of Tumours of the Digestive System","author":"Bosman FT","year":"2010","edition":"4"},{"key":"bibr17-1066896917752862","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-016-1958-1"},{"key":"bibr18-1066896917752862","doi-asserted-by":"publisher","DOI":"10.1159\/000125551"},{"key":"bibr19-1066896917752862","first-page":"164934","volume":"2012","author":"Schwock J","year":"2012","journal-title":"Patholog Res Int"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896917752862","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1066896917752862","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896917752862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:22:03Z","timestamp":1777458123000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1066896917752862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,10]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1177\/1066896917752862"],"URL":"https:\/\/doi.org\/10.1177\/1066896917752862","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,10]]}}}