{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:10:52Z","timestamp":1787019052468,"version":"build-2736575974"},"reference-count":17,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Int J Surg Pathol"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>We present a case of a malignant Ewing-like neoplasm of the parotid gland in a 20-year-old woman with an EWSR1-KLF15 gene fusion that presented with pulmonary metastasis. Despite the fact that the tumor was essentially immunohistochemically negative for keratins, p63, and p40, we interpret this neoplasm as an unusual form of a high-grade myoepithelial carcinoma based on its focal plasmacytoid cytology, chondromyxoid matrix, SOX10, S100 protein, and calponin expression, and the knowledge that the EWSR1-KLF15 gene fusion has, to date, only been identified in 2 tumors, both myoepithelial carcinomas of the kidney. We also present a cytogenetic analysis of this unusual tumor. This \u201cEwing-like myoepithelial carcinoma\u201d initially did not respond to 2 cycles of ifosfamide and etoposide alternated with a cycle of cytoxan, adriamycin, and vincristine, a standard regimen for Ewing sarcoma. Subsequent oral pazopanib therapy did result in a reduction of the patient\u2019s pulmonary and nodal disease.<\/jats:p>","DOI":"10.1177\/1066896918755009","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T01:28:58Z","timestamp":1517534938000},"page":"440-447","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Malignant Ewing-Like Neoplasm With an\n                    <i>EWSR1-KLF15<\/i>\n                    Fusion: At the Crossroads of a Myoepithelial Carcinoma and a Ewing-Like Sarcoma. A Case Report With Treatment Options"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2313-463X","authenticated-orcid":false,"given":"Todd M.","family":"Stevens","sequence":"first","affiliation":[{"name":"University of Alabama at Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morad","family":"Qarmali","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Morlote","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fady M.","family":"Mikhail","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Swensen","sequence":"additional","affiliation":[{"name":"Caris Life Sciences, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoran","family":"Gatalica","sequence":"additional","affiliation":[{"name":"Caris Life Sciences, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene P.","family":"Siegal","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Conry","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,2,1]]},"reference":[{"key":"bibr1-1066896918755009","doi-asserted-by":"publisher","DOI":"10.1111\/his.12281"},{"key":"bibr2-1066896918755009","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20819"},{"key":"bibr3-1066896918755009","volume-title":"WHO Classification of Tumours of the Soft Tissue and Bone","author":"Fletcher CDM","year":"2013","edition":"4"},{"key":"bibr4-1066896918755009","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000167056.13614.62"},{"key":"bibr5-1066896918755009","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000460"},{"key":"bibr6-1066896918755009","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-014-0558-0"},{"key":"bibr7-1066896918755009","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20706"},{"key":"bibr8-1066896918755009","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200102000-00022"},{"key":"bibr9-1066896918755009","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200003000-00010"},{"key":"bibr10-1066896918755009","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-011-1138-2"},{"key":"bibr11-1066896918755009","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e318244ff4b"},{"key":"bibr12-1066896918755009","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000545"},{"key":"bibr13-1066896918755009","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-017-4558-2"},{"key":"bibr14-1066896918755009","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-015-0226-8"},{"key":"bibr15-1066896918755009","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00058.2009"},{"key":"bibr16-1066896918755009","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20587"},{"key":"bibr17-1066896918755009","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.19.7319-7331.2000"}],"container-title":["International Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896918755009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1066896918755009","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1066896918755009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:22:05Z","timestamp":1777458125000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1066896918755009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,1]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1177\/1066896918755009"],"URL":"https:\/\/doi.org\/10.1177\/1066896918755009","relation":{},"ISSN":["1066-8969","1940-2465"],"issn-type":[{"value":"1066-8969","type":"print"},{"value":"1940-2465","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,1]]}}}